61-72-3 Usage
Description
Different sources of media describe the Description of 61-72-3 differently. You can refer to the following data:
1. Cloxacillin induced contact dermatitis in a pharmaceutical
factory worker with positive reactions to
ampicillin but not to penicillin.
2. The chemical formula of this is 3-o-chlorophenyl-5-methyl-4-isoxazolyl
penicillin (Knudsen et al., 1962); this differs from oxacillin only by
an additional chlorine atom. It comes as oral capsules of 250 and
500 mg, and in an injectable formulation of 250 mg, 500 mg, and 2 g. It
is also available as an oral solution of 120 mg/5 ml.
Uses
Antibacterial.
Brand name
Allypropymal;Alurate sodium;Aprozal;Isonal;Nervisal;Numal;Somnipron.
Therapeutic Function
Antibacterial
World Health Organization (WHO)
Ampicillin and cloxacillin are listed separately in the WHO Model
List of Essential Drugs.
Contact allergens
Cloxacillin is a semisynthetic penicillin close to oxacillin.
It induced contact dermatitis in a pharmaceutical
factory worker with positive reactions to ampicillin,
but not to penicillin. In cutaneous drug reactions such
as acute generalized exanthematous pustulosis due to
amoxicillin, cross-reactivity is frequent to cloxacillin
(personal observations).
Purification Methods
Purify mandelic acid by Soxhlet extraction with *C6H6 (about 6mL/g) and allow the extract to crystallise. It can also be recrystallised from CHCl3. The S-benzylisothiuronium salt has m 169o (166o) (from H2O). Dry it at room temperature under vacuum. [Beilstein 10 IV 565.]
Check Digit Verification of cas no
The CAS Registry Mumber 61-72-3 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 6 and 1 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 61-72:
(4*6)+(3*1)+(2*7)+(1*2)=43
43 % 10 = 3
So 61-72-3 is a valid CAS Registry Number.
InChI:InChI=1/C19H18ClN3O5S/c1-8-11(12(22-28-8)9-6-4-5-7-10(9)20)15(24)21-13-16(25)23-14(18(26)27)19(2,3)29-17(13)23/h4-7,13-14,17H,1-3H3,(H,21,24)(H,26,27)/t13-,14+,17-/m1/s1
61-72-3Relevant articles and documents
LIQUID PHARMACEUTICAL FOR ORAL DELIVERY
-
, (2008/06/13)
A liquid pharmaceutical for oral delivery wherein at the time of use, a solid unit dosage form is added to the liquid wherein the unit dosage form is comprised of a substrate soluble in the liquid and a particulate pharmaceutically active material in a pharmaceutically effective amount. At the time of use, the unit dosage form is added to the liquid, without requiring measurement of the liquid, and the entire liquid is consumed to provide for oral delivery of the pharmaceutically effective amount of material.
Enhancement of the efficacy of nifedipine by deuteration
-
, (2008/06/13)
A method of enhancing the efficiency and increasing the duration of action of drugs (e.g. dihydropyridines and anti-bacterials) and particularly of nifedipine and penicillins wherein one or more hydrogen atoms are deuterated and wherein the deuterated drug has unexpectedly improved properties when used in much lower concentrations than unmodified drug. A method for determining the identity and bioequivalency of a new drug is also disclosed wherein the molecular and isotope structure of a new drug is determined by isotope ratio mass spectrometry and compared with the molecular and isotope structure of a known human drug.
