61123-13-5

Basic information

• Product Name: PYR-PHE-PHE-GLY-LEU-MET-NH2
• Synonyms: [PYR1]-SUBSTANCE P (6-11);(PYR6)-SUBSTANCE P (6-11);PYR-PHE-PHE-GLY-LEU-MET-NH2;SUBSTANCE P [PGLU6]-FRAGMENT 6-11;PGLU-PHE-PHE-GLY-LEU-MET-NH2;[GLP6] SUBSTANCE P (6-11);GLP-PHE-PHE-GLY-LEU-MET-NH2;pglu6-substance P fragment 6-11
• CAS NO: 61123-13-5
• Molecular Formula: C₃₆H₄₉N₇O₇S
• Molecular Weight: 723.88
• Mol File: 61123-13-5.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 1195.9°C at 760 mmHg
• Flash Point: 677°C
• Appearance: /
• Density: 1.247g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.579
• Storage Temp.: −20°C
• CAS DataBase Reference: PYR-PHE-PHE-GLY-LEU-MET-NH2(CAS DataBase Reference)
• NIST Chemistry Reference: PYR-PHE-PHE-GLY-LEU-MET-NH2(61123-13-5)
• EPA Substance Registry System: PYR-PHE-PHE-GLY-LEU-MET-NH2(61123-13-5)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 61123-13-5(Hazardous Substances Data)

Usage

General Description

PYR-PHE-PHE-GLY-LEU-MET-NH2 is a peptide chain composed of the amino acids pyroglutamate, phenylalanine, glycine, leucine, and methionine, followed by an amidated carboxy terminus. Pyroglutamate is a modified form of glutamine, where the terminal nitrogen is linked to the γ-carboxyl group of glutamate, resulting in a cyclic structure. Phenylalanine is an essential amino acid involved in the synthesis of proteins, while glycine is a non-essential amino acid that serves as a building block for various proteins. Leucine and methionine are also essential amino acids that contribute to protein synthesis and various metabolic processes. The amidated carboxy terminus confers stability to the peptide chain and may influence its biological activity. Overall, the combination of these amino acids in PYR-PHE-PHE-GLY-LEU-MET-NH2 suggests potential roles in protein structure, function, and signaling processes in biological systems.

InChI:InChI=1/C36H49N7O7S/c1-22(2)18-27(35(49)41-25(32(37)46)16-17-51-3)40-31(45)21-38-33(47)28(19-23-10-6-4-7-11-23)42-36(50)29(20-24-12-8-5-9-13-24)43-34(48)26-14-15-30(44)39-26/h4-13,22,25-29H,14-21H2,1-3H3,(H2,37,46)(H,38,47)(H,39,44)(H,40,45)(H,41,49)(H,42,50)(H,43,48)/t25-,26-,27-,28-,29-/m0/s1

Upstream product

• 73148-99-9 N-t-Boc-Phe-Phe-Gly-Leu-Met-NH₂ 
• 66876-64-0 Boc-Phe-Phe-Gly-OMe 
• 82816-76-0 N-tert-butoxycarbonyl-L-phenylalanine-L-phenylalanine-glycine 
• 2131-00-2 leucyl-methionine amide hydrochloride 
• 7625-57-2 methyl 2-((2S)-2-((tert-butoxycarbonyl)amino)-3-phenylpropanamido)acetate 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 2280-68-4 N-tert-butoxycarbonyl-L-leucyl-L-methioninamide 
• 13139-15-6 N-tert-butoxycarbonyl-L-leucine 
• 77511-08-1 pyroglutamyl-phenylalanyl-phenylalanine methyl ester 
• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 
• 4892-10-8 N-(benzyloxycarbonyl)-L-phenylalanyl-L-phenylalanine methyl ester 
• 2578-84-9 N-benzyloxycarbonyl-L-phenylalanine p-nitrophenyl ester 
• 51165-05-0 H-Phe-Phe-Gly-Leu-Met-NH₂ 
• 2650-64-8 Cbz-L-Gln 

Downstream Products

• 56104-22-4 pGlu-Gln-Phe-Phe-Gly-Leu-Met_.NH₂ 
• 109003-57-8 Z-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH₂ 

Relevant articles and documents

Activity of the C-terminal part of substance P on guinea pig ileum and trachea preparations I. N-acylated pentapeptides SP(7-11)

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Catalytic Transfer Hydrogenation in Synthesis of Substance P

The utility of catalytic transfer hydrogenation (CTH) in the synthesis of longer peptides has been demonstrated by the stepwise synthesis of Substance P in the solution phase.The technique of CTH using formic acid as a hydrogen donor provides a facile method for the removal of protecting groups such as benzyloxycarbonyl and nitro in the synthesis of medium-sized peptides also.Except in the case of glutaminyl peptides where the purity and yield are affected to some extent by cyclization, the products are generally pure requiring minimum purification and the yields are good.