6119-12-6

Basic information

• Product Name: 1-(4-CHLOROPHENYL)-3-HYDROXY-4,5-DIHYDRO-1H-PYRAZOLE
• Synonyms: 1-(4-CHLOROPHENYL)-3-HYDROXY-4,5-DIHYDRO-1H-PYRAZOLE;1-(4-Chlorophenyl)-3-pyrazolidinone
• CAS NO: 6119-12-6
• Molecular Formula: C₉H₉ClN₂O
• Molecular Weight: 196.63
• Mol File: 6119-12-6.mol
• Article Data: 13

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(4-CHLOROPHENYL)-3-HYDROXY-4,5-DIHYDRO-1H-PYRAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-CHLOROPHENYL)-3-HYDROXY-4,5-DIHYDRO-1H-PYRAZOLE(6119-12-6)
• EPA Substance Registry System: 1-(4-CHLOROPHENYL)-3-HYDROXY-4,5-DIHYDRO-1H-PYRAZOLE(6119-12-6)

Safety Data

• Hazardous Substances Data: 6119-12-6(Hazardous Substances Data)

Usage

General Description

1-(4-Chlorophenyl)-3-hydroxy-4,5-dihydro-1H-pyrazole, also known as T0070907, is a chemical compound belonging to the class of pyrazoles. It is a selective peroxisome proliferator-activated receptor gamma (PPARγ) antagonist, which means it can block the activity of PPARγ, a nuclear receptor involved in the regulation of glucose and lipid metabolism. T0070907 has been studied for its potential role in the treatment of various metabolic diseases, including type 2 diabetes and obesity, by modulating PPARγ activity. Its structure includes a 4-chlorophenyl group and a hydroxy group, along with a pyrazole ring, making it a valuable tool compound in research related to PPARγ function and metabolic disorders.

Upstream product

• 107-13-1 acrylonitrile 
• 1073-69-4 N-4-chlorophenylhydrazine 
• 79-06-1 2-propenamide 
• 64-17-5 ethanol 
• 1073-70-7 4-chlorophenylhydrazine hydrochloride 
• 76205-19-1 1-(para-chlorophenyl)-3-hydroxypyrazole 
• 106-47-8 4-chloro-aniline 
• 292638-85-8 acrylic acid methyl ester 
• 6508-11-8 3-Amino-1-(4-chlorophenyl)-2-pyrazoline 
• 76227-93-5 ethyl 3-((4-chlorophenyl)amino)propanoate 
• 21617-19-6 3-(4-chlorophenylamino)propionic acid 
• 625-36-5 2-chloropropionyl chloride 
• 140-88-5 ethyl acrylate 

Downstream Products

• 76205-19-1 1-(para-chlorophenyl)-3-hydroxypyrazole 
• 1284183-64-7 methyl 2-((1-(4-chlorophenyl)-1H-pyrazol-3-yloxy)methyl)-4-iodophenyl(methoxy)carbamate 
• 1284183-66-9 tert-butyl 6-(3-((1-(4-chlorophenyl)-1H-pyrazol-3-yloxy)methyl)-4-(methoxy(methoxycarbonyl)amino)phenyl)hex-5-ynoate 
• 1284183-67-0 tert-butyl 6-(3-((1-(4-chlorophenyl)-1H-pyrazol-3-yloxy)methyl)-4-(methoxy(methoxycarbonyl)amino)phenyl)hexanoate 
• 1284183-69-2 6-(3-((1-(4-chlorophenyl)-1H-pyrazol-3-yloxy)methyl)-4-(methoxy(methoxycarbonyl)amino)phenyl)hexanoic acid 

Relevant articles and documents

Design, synthesis, and fungicidal activity of novel 1,3,4-oxadiazole derivatives

Employing the intermediate derivatization method (IDM), twenty novel 1,3,4-oxadiazole derivatives containing arylpyrazoloxyl moiety were designed and synthesized. The structures of the title compounds were identified by 1H NMR, 13C NMR, MS and elemental analyses, compound 4 was further identified by single-crystal X-ray diffraction. Antifungal activities against rice sheath blight (RSB) and sorghum anthracnose (SA) were evaluated by the mycelium linear growth rate method. Compounds 4, 16 and 20 displayed significant activities against RSB (EC50 = 0.88 mg/L, 0.91 mg/L and 0.85 mg/L, respectively), higher than the reference tebuconazole; While compound 3 exhibited higher activity against SA (EC50 = 1.03 mg/L), equal to commercial pyraclostrobin (EC50 = 1.06 mg/L). The study showed that compound 20 is a promising fungicide for further development.

Preparation method of 1-(4-chlorphenyl)-2H-pyrazoline-3-ketone

The invention relates to a preparation method of 1-(4-chlorphenyl)-2H-pyrazoline-3-ketone, an intermediate reacts with hydrogen peroxide under the action of alkali and a catalyst to generate the 1-(4-chlorphenyl)-2H-pyrazoline-3-ketone, and the structural formula of the intermediate is that the feeding molar ratio of the intermediate to the catalyst is 1: (0.0001-0.001). The preparation method of the 1-(4-chlorphenyl)-2H-pyrazoline-3-ketone has the advantages of simplicity in operation, low catalyst dosage, few three wastes, high efficiency and high yield, and is suitable for industrial production.

COMPOUND HAVING BET INHIBITORY ACTIVITY AND PREPARATION METHOD AND USE THEREFOR

The invention relates to the field of pharmaceutical chemistry. Specifically, the present invention relates to a series of BET (bromodomain and extra-terminal domain) inhibitors having a novel structure, particularly inhibitors targeting BRD4 (Bromodomain-containing protein 4), and a preparation method and use therefor. The structure thereof is shown in the following general formula (I). Said compounds or a stereoisomer, racemate, geometric isomer, tautomer, prodrug, hydrate, solvate, or crystal form thereof, or a pharmaceutically acceptable salt thereof, and the pharmaceutical compsosition thereof can be used for the treatment and/or prevention of related diseases mediated by bromodomain proteins.