76205-19-1Relevant articles and documents
Environment-friendly synthesis process of 1-(4-chlorphenyl)-3-pyrazole alcohol
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Paragraph 0033-0048, (2021/03/13)
;The invention discloses a green synthesis process of 1-(4-chlorphenyl)-3-pyrazole alcohol, and the process comprises the following steps: adding p-chloroaniline, absolute ethyl alcohol and sodium ethoxide serving as raw materials into a four-neck flask with a mechanical stirrer and a reflux condensing tube box thermometer, performing stirring until the raw materials are dissolved, slowly adding p-chlorophenylhydrazine hydrochloride, and slowly dropwise adding ethyl acrylate after the reaction is finished, recovering absolute ethyl alcohol through reduced pressure distillation, adding water into residues, uniformly stirring, adjusting the pH value to 2 with hydrochloric acid, separating out solids, performing washing with water, performing drying to obtain a product, adding water into residues obtained after ethanol is recovered through reduced pressure distillation in synthesis of 1-(4-chlorphenyl)-3-pyrazol, performing heating, slowly dropwise adding hydrogen peroxide, and performingcooling to room temperature after the reaction is finished; and adjusting precipitated solids with hydrochloric acid, performing washing with water and performing drying for 10 minutes to obtain theproduct. According to the present invention, the 1-(4-chlorphenyl)-3-pyrazole alcohol synthesis method is reasonable, and the synthesized 1-(4-chlorphenyl)-3-pyrazole alcohol has high efficiency.
Preparation method of pyraclostrobin intermediate
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Paragraph 0032; 0064-0065, (2021/09/15)
The invention discloses a preparation method of pyraclostrobin intermediate 3 - hydroxyl - 1H - pyrazole and 1 - (4 - chlorophenyl) -3 - pyrazol, which comprises: synthesizing 3 - hydroxyl - 1H - pyrazole -4 - carboxylic acid ethyl ester by cyclization re
Synthesis method and application of 1-(4-chlorphenyl)-3-pyrazole alcohol
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Paragraph 0020-0027, (2020/05/01)
The invention belongs to the field of chemical drug synthesis, and discloses a synthesis method and application of 1-(4-chlorphenyl)-3-pyrazole alcohol. The synthesis method comprises the steps: preparing 2-(chloromethyl)-1,3-dioxolane from ethylene glycol and chloroacetaldehyde in the presence of a catalyst, reacting with cyanide to prepare 3-oxopropionamide, and carrying out cyclization reactionon p-chlorophenylhydrazine hydrochloride and 3-oxopropionamide to obtain the cyclization product 1-(4-chlorphenyl)-3-pyrazol with purity higher than 96%. The synthesized 1-(4-chlorphenyl)-3-pyrazolealcohol can be used as an important intermediate in the synthesis process of the bactericide pyraclostrobin.