61337-89-1

Basic information

• Product Name: 1-(3-Hydroxymethylpyridin-2-yl)-4-methyl-2-phenylpiperazine
• Synonyms: [2-(4-METHYL-2-PHENYLPIPERAZIN-1-YL)PYRIDIN-3-YL]METHANOL;2-(4-METHYL-2-PHENYL-1-PIPERAZINYL)-3-PYRIDINEMETHANOL;1-(3-HYDROXYMETHYL PYRIDIN-2-YL)-4-METHYL-2-PHENYL PIPERAZINE;1-(3-HYDROXYMETHYLPYRIDINE)-2-PHENYL-4-METHYL-PIPERAZINE;1-(3-HYDROXIDMETHYLPYRIDINE)-2-PHENYL-4-METHYL-PIPERAZINE;1-(3-Hydroxymethylpyridyl-2)-2-Phenyl-4-Methylpyperazine;1-(3-Hydroxymethylpyridin-2-Yl;2-(4-methyl-2-phenyl-1-piperazinyl)-3-pyridinemethanol (intermediate of mirtazapine)
• CAS NO: 61337-89-1
• Molecular Formula: C17H21N3O
• Molecular Weight: 283.37
• EINECS: 1308068-626-2
• Product Categories: Alkohols;Organic acids;Piperazine derivates;(intermediate of mirtazapine);(intermediate of azelastine hcl);l(intermediate of mirtazapine);Aromatics;Heterocycles;Miscellaneous Reagents;Intermediate Mirtazapine
• Mol File: 61337-89-1.mol
• Article Data: 19

Chemical Properties

• Melting Point: 113-115°C
• Boiling Point: 478.753 °C at 760 mmHg
• Flash Point: 243.341 °C
• Appearance: White solid
• Density: 1.161 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.602
• Storage Temp.: -20°C Freezer, Under Inert Atmosphere
• Solubility: DMSO (Sparingly), Methanol (Slightly)
• PKA: 13.59±0.10(Predicted)
• CAS DataBase Reference: 1-(3-Hydroxymethylpyridin-2-yl)-4-methyl-2-phenylpiperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-Hydroxymethylpyridin-2-yl)-4-methyl-2-phenylpiperazine(61337-89-1)
• EPA Substance Registry System: 1-(3-Hydroxymethylpyridin-2-yl)-4-methyl-2-phenylpiperazine(61337-89-1)

Safety Data

• Hazardous Substances Data: 61337-89-1(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

Different sources of media describe the Uses of 61337-89-1 differently. You can refer to the following data:
1. An impurity found in Mirtazapine (M365000). Mirtazapine Impurity B.
2. 2-(4-Methyl-2-phenyl-1-piperazinyl)-3-pyridinemethanol is an impurity found in Mirtazapine (M365000). Mirtazapine Impurity B.

InChI:InChI=1/C17H21N3O/c1-19-10-11-20(17-15(13-21)8-5-9-18-17)16(12-19)14-6-3-2-4-7-14/h2-9,16,21H,10-13H2,1H3

Upstream product

• 61338-13-4 2-(4-methyl-2-phenyl-1-piperazinyl)-3-pyridinecarboxylic acid 
• 10366-35-5 2-chloronicotinamide 
• 13362-26-0 2-aminopyridine-3-carboxylic acid ethyl ester 
• 61337-88-0 3-cyano-2-(4-methyl-2-phenyl-1-piperazynyl)pyridine 
• 5271-27-2 1-methyl-3-phenylpiperazine 
• 6602-54-6 2-chloro-3-pyridinecarbonitrile 

Downstream Products

• 85650-52-8 Mirtazapine 
• 24219-97-4 mianserin 

Relevant articles and documents

A synthesis method of midanping

The invention discloses a method for synthesizing mirtazapine. According to the method, 2-halogenated nicotinonitrile is used as an initial compound, and 2-chloronicotinamide, 2-(4-methyl-2phenyl-1-piperazinyl)nicotinamide, 2-(4-methyl-2phenyl-1-piperazinyl)nicotinic acid, 1-(3-hydroxymethylpyridyl-2-)-4-methyl-2-phenylpiperazine and other intermediate products are sequentially synthesized to prepare the mirtazapine. Against the defects in a current mirtazapine synthesizing method, the process is improved, a new synthesizing route is designed, and a preparation method which is economical and is easy for practical operation is provided to mirtazapine synthesis. The method is suitable for large-scale industrial production.

MANUFACTURING METHOD OF PYRIDINEMETHANOL COMPOUND AND MANUFACTURING METHOD OF MIRTAZAPINE

PROBLEM TO BE SOLVED: To provide a method capable of manufacturing a manufacturing intermediate of mirtazapine which is useful as an antidepressant at high yield and manufacturing high purity mirtazapine. SOLUTION: In a method for reacting 2-(4-methyl-2-phenyl-1-piperazinyl)-3-pyridinecarboxylic acid and hydrogenated bis(2-methoxyethoxy)aluminum sodium, manufacturing yield of 2-(4-methyl-2-phenyl-1-piperazinyl)-3-pyridine methanol is improved by washing a reaction mixture with alkali metal halide. Also in the method, by-production amount of dimer impurities during reaction can be suppressed and high quality mirtazapine can be manufactured in a method for reaction 2-(4-methyl-2-phenyl-1-piperazinyl)-3-pyridine methanol and sulfuric acid. SELECTED DRAWING: None COPYRIGHT: (C)2017,JPOandINPIT

MANUFACTURING METHOD OF MIRTAZAPINE

PROBLEM TO BE SOLVED: To provide a method capable of manufacturing mirtazapine useful as antidepressant at high quality and high manufacturing yield without needs for complicated purification operation. SOLUTION: Mirtazapine with largely suppressed by-production amount of impurities during reaction can be manufactured by reacting with use of sulfuric acid with concentration of 85.0% or more and less than 96.0% in a method for manufacturing mirtazapine by reacting 2-(4-methyl-2-phenyl)-1-piperazinyl)-3-pyridinemethanol and sulfuric acid. SELECTED DRAWING: None COPYRIGHT: (C)2017,JPO&INPIT