617689-07-3

Basic information

• Product Name: 5-Methoxy-2-methyl benzeneboronic acid
• Synonyms: 5-Methoxy-2-methyl benzeneboronic acid;2-Methyl-5-Methoxy-phenylboronic acid;(5-Methoxy-2-methylphenyl)
• CAS NO: 617689-07-3
• Molecular Formula: C₈H₁₁BO₃
• Molecular Weight: 165.98214
• Mol File: 617689-07-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 334.9±52.0 °C(Predicted)
• Appearance: /
• Density: 1.14±0.1 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 8.18±0.58(Predicted)
• CAS DataBase Reference: 5-Methoxy-2-methyl benzeneboronic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Methoxy-2-methyl benzeneboronic acid(617689-07-3)
• EPA Substance Registry System: 5-Methoxy-2-methyl benzeneboronic acid(617689-07-3)

Safety Data

• Hazardous Substances Data: 617689-07-3(Hazardous Substances Data)

Usage

Uses

(5-Methoxy-2-methylphenyl)boronic Acid is used in preparation of Phenyl-substituted Imidazopyridine Amides useful in the treatment of cardiovascular and other disorders.

Upstream product

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Relevant articles and documents

ENANTIOPURE TERPHENYLS WITH TWO ORTHO-ATROPISOMERIC AXES

Enantiopure terphenyl presenting two ortho-located chiral axes having the following structural formula (I) : their process of synthesis and their use as mono or bidentate ligands for asymmetric organometallic reactions, as organocatalysts, as chiral base

Fast and Tight Boronate Formation for Click Bioorthogonal Conjugation

A new click bioorthogonal reaction system was devised to enable the fast ligation (kON≈340 m-1 s-1) of conjugatable derivatives of a rigid cyclic diol (nopoldiol) and a carefully optimized boronic acid partner, 2-methyl-5-carboxymethylphenylboronic acid. Using NMR and fluorescence spectroscopy studies, the corresponding boronates were found to form reversibly within minutes at low micromolar concentration in water, providing submicromolar equilibrium constant (Keq≈105-106 m-1). Efficient protein conjugation under physiological conditions was demonstrated with model proteins thioredoxin and albumin, and characterized by mass spectrometry and gel electrophoresis.