62062-39-9

Basic information

• Product Name: 1-(naphthalen-1-yl)piperidine
• CAS NO: 62062-39-9
• Molecular Formula: C₁₅H₁₇N
• Molecular Weight: 211.3022
• Mol File: 62062-39-9.mol
• Article Data: 24

Chemical Properties

• Boiling Point: 362.9°C at 760 mmHg
• Flash Point: 156.2°C
• Density: 1.079g/cm³
• Vapor Pressure: 1.88E-05mmHg at 25°C
• Refractive Index: 1.621
• CAS DataBase Reference: 1-(naphthalen-1-yl)piperidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(naphthalen-1-yl)piperidine(62062-39-9)
• EPA Substance Registry System: 1-(naphthalen-1-yl)piperidine(62062-39-9)

Safety Data

• Hazardous Substances Data: 62062-39-9(Hazardous Substances Data)

Usage

Chemical structure

A piperidine derivative with a naphthalene group attached to the piperidine ring.

Organic synthesis

Used as a building block for more complex molecules.

Pharmacological activities

Investigated for potential drug targeting the central nervous system.

Subject to strict regulations

Due to structural similarity to other psychoactive compounds, its use and research are controlled in many countries.

Versatility

Diverse applications in both research and industry.

Upstream product

• 111-24-0 1,5-dibromo-pentane 
• 134-32-7 1-amino-naphthalene 
• 110-89-4 piperidine 
• 68211-49-4 1-naphthyl tosylate 
• 3402-76-4 1-phenoxynaphthalene 
• 90-14-2 1-Iodonaphthalene 
• 4801-58-5 N-hydroxypiperidine 
• 91-20-3 naphthalene 
• 110210-11-2 1-(2,4-dinitrophenoxy)piperidine 
• 2216-69-5 1-Methoxynaphthalene 
• 5542-49-4 piperidin-1-yl benzoate 
• 90-13-1 1-Chloronaphthalene 
• 90-11-9 1-Bromonaphthalene 
• 321-38-0 1-Fluoronaphthalene 

Downstream Products

• 1027919-53-4 4,4'-di(piperidin-1-yl)-1,1'-binaphthyl 
• 202983-74-2 C₃₂H₃₇N₃ 

Relevant articles and documents

Iodine-Mediated Coupling of Cyclic Amines with Sulfonyl Hydrazides: an Efficient Synthesis of Vinyl Sulfone Derivatives

An efficient iodine-mediated coupling of cyclic amines with sulfonyl hydrazides is reported. This transformation opens a new route to the synthesis of vinyl sulfones derivatives, which is a common structural motif in natural products and pharmaceuticals. Tentative mechanistic studies suggest that this reaction is likely to involve a radical process.

Leaving Group Ability in Nucleophilic Aromatic Amination by Sodium Hydride-Lithium Iodide Composite

The methoxy group is generally considered as a poor leaving group for nucleophilic substitution reactions. This work verified the superior ability of the methoxy group in nucleophilic amination of arenes mediated by the sodium hydride and lithium iodide through experimental and computational approaches.

Practical and regioselective amination of arenes using alkyl amines

The formation of carbon–nitrogen bonds for the preparation of aromatic amines is among the top five reactions carried out globally for the production of high-value materials, ranging from from bulk chemicals to pharmaceuticals and polymers. As a result of this ubiquity and diversity, methods for their preparation impact the full spectrum of chemical syntheses in academia and industry. In general, these molecules are assembled through the stepwise introduction of a reactivity handle in place of an aromatic C–H bond (that is, a nitro group, halogen or boronic acid) and a subsequent functionalization or cross-coupling. Here we show that aromatic amines can be constructed by direct reaction of arenes and alkyl amines using photocatalysis, without the need for pre-functionalization. The process enables the easy preparation of advanced building blocks, tolerates a broad range of functionalities, and multigram scale can be achieved via a batch-to-flow protocol. The merit of this strategy as a late-stage functionalization platform has been demonstrated by the modification of several drugs, agrochemicals, peptides, chiral catalysts, polymers and organometallic complexes.