6240-96-6

Basic information

• Product Name: (R)-1-(Cyclopropylethyl)amine
• Synonyms: (R)-1-CYCLOPROPYLETHYLAMINE;(R)-1-Cyclopropylethylamine, ChiPros 98%, ee 98+%;(R)-1-CyclopropylethylaMine, ChiPros|r, 98%, ee 98+%;(R)-1-Cyclopropylethylamine ChiPros(R), produced by BASF, 99%;(R)-1-cyclopropylethan-1-amine
• CAS NO: 6240-96-6
• Molecular Formula: C₅H₁₁N
• Molecular Weight: 85.15
• Mol File: 6240-96-6.mol
• Article Data: 7

Chemical Properties

• Melting Point: -68℃
• Boiling Point: 95°C
• Flash Point: 95°C
• Appearance: /
• Density: 0.920
• Vapor Pressure: 33.4mmHg at 25°C
• Refractive Index: 1.486
• PKA: 10.87±0.29(Predicted)
• Water Solubility: Miscible with water.
• Sensitive: Air Sensitive
• CAS DataBase Reference: (R)-1-(Cyclopropylethyl)amine(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-1-(Cyclopropylethyl)amine(6240-96-6)
• EPA Substance Registry System: (R)-1-(Cyclopropylethyl)amine(6240-96-6)

Safety Data

• Hazard Codes: T
• Statements: 10-25-34-52
• Safety Statements: 26-36/37/39-45
• RIDADR: UN2735
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 6240-96-6(Hazardous Substances Data)

Usage

Uses

(R)-1-Cyclopropylethylamine is used for resolution of organic compounds in organic synthesis.

InChI:InChI=1/C5H11N/c1-4(6)5-2-3-5/h4-5H,2-3,6H2,1H3/t4-/m1/s1

Upstream product

• 51761-72-9 cyclopropyl methyl ketone oxime 
• 765-43-5 Cyclopropyl methyl ketone 
• 100-46-9 benzylamine 
• 72-19-5 L-threonine 
• 6240-96-6 1-cyclopropylethylamine 

Downstream Products

• 1033407-78-1 5-chloro-N-(1-cyclopropylethyl)-2-nitrobenzamide 
• 765-43-5 Cyclopropyl methyl ketone 
• 1492-24-6 L-2-aminobutyric acid 
• 6240-96-6 (1R)-1-cyclopropylethan-1-amine 
• 886583-69-3 3-bromo-1-(3-chloro-2-pyridinyl)-N-[4-cyano-2-[[(1-cyclopropylethyl)amino]carbonyl]-6-methylphenyl]-1H-pyrazole-5-carboxamide 
• 886583-56-8 3-bromo-N-[4-chloro-2-[[(1-cyclopropylethyl)amino]carbonyl]-6-methylphenyl]-1-(2-chlorophenyl)-1H-pyrazole-5-carboxamide 
• 1382782-42-4 (R)-5-(1-cyclopropyl-ethyl)-2-phenoxymethyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazin-4-one 
• 512847-52-8 (1-cyclopropyl-ethyl)-[4-(2,4-dichloro-phenyl)-3-nitro-pyridin-2-yl]-amine 
• 195604-39-8 (+)-1-cyclopropylethylamine 
• 53651-34-6 1-(3-Bromo-4-ethoxy-2,5,6-trimethyl-phenoxy)-3-(1-cyclopropyl-ethylamino)-propan-2-ol 
• 53650-43-4 1-(3-Bromo-4-methoxy-2,5,6-trimethyl-phenoxy)-3-(1-cyclopropyl-ethylamino)-propan-2-ol 
• 53650-90-1 1-(1-Cyclopropyl-ethylamino)-3-(4-ethoxy-2,3,6-trimethyl-phenoxy)-propan-2-ol 
• 53649-90-4 1-(1-Cyclopropyl-ethylamino)-3-(4-methoxy-2,3,6-trimethyl-phenoxy)-propan-2-ol 

Relevant articles and documents

SCALABLE SYNTHESIS OF OPTICALLY ACTIVE 1-CYCLOPROPYLALKYL-1-AMINES

The present invention provides a new, scalable synthetic method for the preparation of non-racemic 1-cyclopropyl alkyl-1-amines, e.g. (S)- 1-cyclopropyl ethyl-1-amine. The method makes use of inexpensive starting materials (such as cyclopropyl methyl keto

Asymmetric Amination of Secondary Alcohols by using a Redox-Neutral Two-Enzyme Cascade

Multienzyme cascade approaches for the synthesis of optically pure molecules from simple achiral compounds are desired. Herein, a cofactor self-sufficient cascade protocol for the asymmetric amination of racemic secondary alcohols to the corresponding chiral amines was successfully constructed by employing an alcohol dehydrogenase and a newly developed amine dehydrogenase. The compatibility and the identical cofactor dependence of the two enzymes led to an ingenious in situ cofactor recycling system in the one-pot synthesis. The artificial redox-neutral cascade process allowed the transformation of racemic secondary alcohols into enantiopure amines with considerable conversions (up to 94 %) and >99 % enantiomeric excess at the expense of only ammonia; this method thus represents a concise and efficient route for the asymmetric synthesis of chiral amines. If you know what amine: A redox-neutral two-enzyme cascade encompassing an alcohol dehydrogenase (ADH) and an amine dehydrogenase (AmDH) is constructed for the synthesis of chiral amines from the corresponding racemic alcohols in one pot to afford considerable conversions (up to 94 %) and high enantiomeric excess values (>99 %) at the expense of only ammonia.

ω-Transaminase-catalyzed kinetic resolution of chiral amines using l-threonine as an amino acceptor precursor

Kinetic resolution of chiral amines using l-threonine as a cosubstrate was demonstrated by a biocatalytic strategy in which (S)-selective ω-transaminase (ω-TA) was coupled with threonine deaminase (TD), eliminating the need to use an expensive keto acid as an amino acceptor. The coupled enzyme reaction enabled simultaneous production of enantiopure (R)-amine and l-homoalanine which are pharmaceutically important building blocks. To extend the versatility of this strategy to production of both enantiomers of chiral amines, (R)-selective ω-TA coupled with TD was employed to produce (S)-amine.