626-05-1Relevant articles and documents
A simple base-mediated halogenation of acidic sp2 C-H bonds under noncryogenic conditions
Do, Hien-Quang,Daugulis, Olafs
supporting information; experimental part, p. 421 - 423 (2009/07/04)
(Chemical Equation Presented) A new method has been developed for in situ halogenation of acidic sp2 carbon-hydrogen bonds in heterocycles and electron-deficient arenes. Either selective monohalogenation or one-step exhaustive polyhalogenation is possible for substrates possessing several C-H bonds that are flanked by electron-withdrawing groups. For the most acidic arenes, such as pentafluorobenzene, K3PO4 base can be employed instead of BuLi for metalation/halogenation sequences.
Process for the synthesis of an endothelin receptor antagonist
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, (2008/06/13)
The present invention relates to a practical and efficient way to synthesize the compound for the endothelin receptor antagonist involving a Grignard addition and a cyclization reaction to give a desired compound of the general formula shown below:
Titanium(0) Reagents; 2. A Selective and Efficient Deoxygenation of Halogen Containing Heteroaromatic N-Oxides
Malinowski, Marek,Kaczmarek, Lukasz
, p. 1013 - 1015 (2007/10/02)
Following successful reductions of unfunctionalized heteroaromatic N-oxides by titanium(0), we applied this method to halogenated aromatic N-oxides to give the deoxygenated halogeno derivatives in 90-95percent yield.