63228-51-3

Basic information

• Product Name: L-aspartic acid beta-benzyl ester
• Synonyms: L-aspartic acid beta-benzyl ester
• CAS NO: 63228-51-3
• Molecular Weight: 223.229
• Mol File: 63228-51-3.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: L-aspartic acid beta-benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-aspartic acid beta-benzyl ester(63228-51-3)
• EPA Substance Registry System: L-aspartic acid beta-benzyl ester(63228-51-3)

Safety Data

• Hazardous Substances Data: 63228-51-3(Hazardous Substances Data)

Upstream product

• 51186-58-4 4-benzyl Boc-D-aspartate 
• 1783-96-6 (2R)-aspartic acid 
• 100-51-6 benzyl alcohol 
• 145126-18-7 3-[[(1,1-dimethylethoxy)carbonyl]amino]-4-oxo-4-(phenylmethoxy)-butanoic acid 
• 617-45-8 aspartic Acid 
• 56-84-8 L-Aspartic acid 

Downstream Products

• 51186-58-4 4-benzyl Boc-D-aspartate 
• 163929-78-0 N-acetyl-D-aspartic acid β-benzyl ester 
• 171976-99-1 (R)-2-[(S)-2-((S)-2-Benzyloxycarbonylamino-3-hydroxy-propionylamino)-3-(4-hydroxy-phenyl)-propionylamino]-succinic acid 4-benzyl ester 
• 346669-80-5 N-[(R)-3-dodecanoyloxytetradecanoyl]-D-aspartic acid β-benzyl ester 
• 51186-60-8 D-Asp(-OCH₂C₆H₅)-L-Asp-NH₂ 
• 51186-59-5 Boc-D-Asp(-O-CH₂C₆H₅)-Asp-NH₂ 
• 446253-68-5 (3R)-3-azido-N-benzylsuccinamic acid methyl ester 
• 207120-06-7 2(R)-[3-[4-(pyridin-4-yl)phenyl]-1H-pyrrol-1-yl]succinic acid 4-benzyl ester hydrochloride 
• 150009-58-8 Fmoc-D-Asp(OBn)-OH 
• 1218935-69-3 C₁₇H₂₅NO₆Si 
• 1313202-26-4 C₂₀H₂₀N₂O₅S 
• 1313202-24-2 C₂₁H₂₆N₂O₇S 
• 1313202-25-3 C₂₁H₂₅ClN₂O₇S 
• 1313202-23-1 C₂₂H₂₈N₂O₇S 

Relevant articles and documents

Thermoresponsive Alignment Media in NMR Spectroscopy: Helix Reversal of a Copolyaspartate at Ambient Temperatures

Poly(aspartic acid esters) are known to form either right-or left-handed α-helices depending on the ester group in the side chain, on solvent and/or on temperature. Polyphenethyl-l-aspartates (PPLA) exhibit a helix reversal from the right- to the left-handed form with increasing temperature. We have recently reported the application of polyphenethylaspartates as helically chiral alignment media. The thermoresponsivity observed for these polymers offers the possibility to measure different orientations of analytes before and after helix reversal of the alignment medium at 373 K. Herein we present a synthesized copolymer of phenethyl- and benzylaspartate as a new alignment medium undergoing this helix reversal at 303–313 K. Thus, the measurement of residual dipolar couplings (RDC) before and after the helix reversal is allowed for at ambient temperatures. A complete sign change of all 1H–13C RDCs was observed, which is close to the highest possible difference in NMR spectra.

Degradation-promoters of cellular inhibitor of apoptosis protein 1 based on bestatin and actinonin

A series of hybrid compounds of bestatin (1) and actinonin (3), which promote degradation of cellular inhibitor of apoptosis protein 1 (cIAP1), were designed and synthesized. Structure-activity relationship studies indicated that absolute configuration, hydrophobicity at the α-position of the internal amide carbonyl group, and the presence of a small substituent at the α-position of the ester group are important factors for the expression of potent cIAP1 degradation-promoting activity. HAB-5A (30b) showed the most potent activity (IC50 = 0.53 μM) among the compounds prepared.

2,3,4,5-TETRAHYDRO-1H-1,5-BENZODIAZEPINE DERIVATIVE AND MEDICINAL COMPOSITION

A 2,3,4,5-tetrahydro-1H-1,5-benzodiazepine derivative represented by the generalformula (1): [Chemical formula 1] (1) or a pharmaceutically acceptable saltthereof. They are useful as a therapeutic/preventive agent for diabetes, diabeticnephropathy, or glomerulosclerosis.