63378-71-2

Basic information

• Product Name: Ethyl 2-Oxo-3-Phenylpiperidine-3-Carboxylate
• Synonyms: Ethyl 2-Oxo-3-Phenylpiperidine-3-Carboxylate
• CAS NO: 63378-71-2
• Molecular Formula: C₁₄H₁₇NO₃
• Molecular Weight: 247.28968
• Mol File: 63378-71-2.mol
• Article Data: 4

Chemical Properties

• Melting Point: 142-143 °C(Solv: water (7732-18-5); ethanol (64-17-5))
• Boiling Point: 425.5°C at 760 mmHg
• Flash Point: 211.2°C
• Appearance: /
• Density: 1.146g/cm³
• Vapor Pressure: 1.9E-07mmHg at 25°C
• Refractive Index: 1.528
• PKA: 15.11±0.40(Predicted)
• CAS DataBase Reference: Ethyl 2-Oxo-3-Phenylpiperidine-3-Carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 2-Oxo-3-Phenylpiperidine-3-Carboxylate(63378-71-2)
• EPA Substance Registry System: Ethyl 2-Oxo-3-Phenylpiperidine-3-Carboxylate(63378-71-2)

Safety Data

• Hazardous Substances Data: 63378-71-2(Hazardous Substances Data)

Usage

General Description

Ethyl 2-oxo-3-phenylpiperidine-3-carboxylate is a chemical compound with the molecular formula C14H17NO3. It is a piperidine derivative that is commonly used in pharmaceutical research and drug development. Ethyl 2-Oxo-3-Phenylpiperidine-3-Carboxylate is known to exhibit potential pharmacological activities, including analgesic and anti-inflammatory properties. Additionally, it has been studied for its potential use in the treatment of neurodegenerative disorders and psychiatric conditions. Ethyl 2-oxo-3-phenylpiperidine-3-carboxylate is a versatile compound with a range of potential applications in the pharmaceutical industry.

InChI:InChI=1/C14H17NO3/c1-2-18-13(17)14(9-6-10-15-12(14)16)11-7-4-3-5-8-11/h3-5,7-8H,2,6,9-10H2,1H3,(H,15,16)

Upstream product

• 738541-91-8 2-(3-Amino-propyl)-2-phenyl-malonic acid diethyl ester 
• 107-13-1 acrylonitrile 
• 83-13-6 diethyl 2-phenylmalonate 
• 10444-14-1 Diethyl 2-(2-cyanoethyl)-2-phenylmalonate 

Downstream Products

• 51551-56-5 (RS)-3-phenylpiperidin-2-one 
• 27768-60-1 ethyl 2-ethoxy-3-phenyl-3,4,5,6-tetrahydropyridine-3-carboxylate 
• 133905-15-4 Ethyl 3-phenyl-2-thioxopiperidine-3-carboxylate 
• 35576-17-1 3-Phenylpiperidine-2-thione 
• 1025954-23-7 2-(3-phenyl-3,4,5,6-tetrahydro-pyridin-2-ylsulfanyl)-malonic acid diethyl ester 
• 1027420-92-3 2-Oxo-3-phenyl-piperidine-3-carbonyl chloride 

Relevant articles and documents

Influence of ring size on the outcome of sulfide contraction reactions with thiolactams. Isolation of bicyclic ketene S,N-acetals and thioisomuenchnones

Reaction between diethyl bromomalonate and 3-phenylpyrrolidine-2-thione yielded a vinylogous urethane by the Eschenmoser sulfide contraction. However, with 3-substituted piperidine-2-thiones, sulfur was retained in the products, and a range of bicyclic heterocycles, including bicyclic ketene S,N-acetals (2-alkylidene-1,3-thiazolidin-4-ones) and stable thioisomuechnones, was isolated. A novel dimeric ketene S,N-acetal was characterised by X-ray crystallography.

Synthesis of new deazatetrahydropterins as potential NO synthase modulators

As part of our research on NO synthase modulators, a series of deazatetrahydropterins were synthesized and their effects were assessed. In this paper, we describe the synthesis of new substituted (especially at the 4a position) 2-amino-4-hydroxy-3,4,4a,5,6,7-hexahydropyrido[2,3-d]pyrimidines. These compounds showed no interesting pharmacological activity. Elsevier.