635724-49-1

Basic information

• Product Name: 1-Pyrrolidinecarboxylic acid, 4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-phenyl-, 1,1-dimethylethyl ester, (2S,4S)-
• Synonyms: tert-butyl(2S,4S)-4-{[tert-butyl(dimethyl)silyl]oxy}-2-phenylpyrrolidine-1-carboxylate;(2S,4S)-tert-butyl 4-{[tert-butyl(dimethyl)silyl]oxy}-2-phenylpyrrolidine-1-carboxylate;(2S,4S)-4-(TERT-BUTYL-DIMETHYL-SILANYLOXY)-2-PHENYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
• CAS NO: 635724-49-1
• Molecular Formula: C21H35NO3Si
• Molecular Weight: 377.599
• Mol File: 635724-49-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-Pyrrolidinecarboxylic acid, 4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-phenyl-, 1,1-dimethylethyl ester, (2S,4S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Pyrrolidinecarboxylic acid, 4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-phenyl-, 1,1-dimethylethyl ester, (2S,4S)-(635724-49-1)
• EPA Substance Registry System: 1-Pyrrolidinecarboxylic acid, 4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-phenyl-, 1,1-dimethylethyl ester, (2S,4S)-(635724-49-1)

Safety Data

• Hazardous Substances Data: 635724-49-1(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 127913-44-4 (S)-4-chloro-3-hydroxy butyronitrile 
• 56522-24-8 tert-butyldimethylsilyl cyanide 
• 884902-55-0 (3S)-3-[(tert-butyldimethylsilyl)oxy]-4-chlorobutanenitrile 

Downstream Products

• 639075-51-7 tert-butyl (2S,4S)-4-{[tert-butyl(dimethyl)silyl]oxy}-2-methyl-2-phenylpyrrolidine-1-carboxylate 
• 639074-56-9 (1S)-1-cyclopropyl-2-[(2S)-4-(2,5-difluorophenyl)-2-phenyl-2,5-dihydro-1H-pyrrol-1-yl]-2-oxoethanamine 
• 635724-47-9 tert-butyl (2S)-2-phenyl-4-{[(trifluoromethyl)sulfonyl]oxy}-2,5-dihydro-1H-pyrrole-1-carboxylate 
• 635724-48-0 tert-butyl (2S)-2-phenyl-4-(2,5-difluorophenyl)-2,5-dihydro-1H-pyrrole-1-carboxylate 
• 884902-61-8 4-(2,5-difluoro-phenyl)-2-phenyl-2,5-dihydro-1H-pyrrole 
• 635724-46-8 tert-butyl (2S)-4-oxo-2-phenylpyrrolidine-1-carboxylate 
• 635724-45-7 tert-butyl (2S,4S)-4-hydroxy-2-phenylpyrrolidine-1-carboxylate 

Relevant articles and documents

Kinesin spindle protein (KSP) inhibitors. Part 2: The design, synthesis, and characterization of 2,4-diaryl-2,5-dihydropyrrole inhibitors of the mitotic kinesin KSP

The evolution of 2,4-diaryl-2,5-dihydropyrroles as inhibitors of KSP is described. Introduction of basic amide and urea moieties to the dihydropyrrole nucleus enhanced potency and aqueous solubility, simultaneously, and provided compounds that caused mito