64952-97-2 Usage
Uses
Different sources of media describe the Uses of 64952-97-2 differently. You can refer to the following data:
1. Latamoxef is an oxacephem antibiotic usually grouped with the cephalosporins. An anti-bacterial agent.
2. Anti-infective.
Definition
ChEBI: A broad-spectrum oxacephem antibiotic in which the oxazine ring is substituted with a tetrazolylthiomethyl group and the azetidinone ring carries methoxy and 2-carboxy-2-(4-hydroxyphenyl)acetamido substituents.
Brand name
Moxam (Lilly);Baxal;Betalactam;Festamoxin;Latoxacet;Mactam;Moxacef;Moxatres;Priollat;Sectam;Shiomalin;Shiomarin.
World Health Organization (WHO)
Latamoxef, a cefamycin antibiotic, was introduced in 1982 for the treatment of serious infections. Its use has subsequently been associated with
reports of clinically important haemorrhage, sometimes fatal, and in some
countries routine co-administration of vitamin K is advised to minimize this risk.
Antimicrobial activity
Moxalactam. A semisynthetic 7-methoxyoxacephem, supplied
as the disodium salt.It is generally slightly
less active than cefotaxime, especially against Staph. aureus,
but unlike other group 4 cephalosporins it exhibits fairly good
activity against B. fragilis. Other Bacteroides spp. are generally
less susceptible. The 7-methoxy substitution, also found in
cephamycins such as cefoxitin, confers resistance to hydrolysis
by a wide range of β-lactamases including those of Staph.
aureus, various enterobacteria and B. fragilis. Resistance, predominantly
in Enterobacter spp., Ps. aeruginosa and Ser. marcescens
due to induction of chromosomal enzymes, has
been found in vitro and in some patients.
A 500 mg intramuscular injection achieves a serum concentration
of 12–22 mg/L after 1.2 h. Infusion of 1 g over
30 min results in a concentration of 60 mg/L. The plasma
half-life is c. 2 h and plasma protein binding 40–50%. There is reasonably good penetration into serous fluids, the concentration
in ascitic fluid reaching 75% and in pleural fluid 50%
of the concentration simultaneously present in the serum.
Levels of 5–35 mg/L have been obtained in inflamed meninges.
Sputum levels are of the order of 2 mg/L following 1 g of
the drug intravenously.
Renal elimination accounts for 90% of the clearance, but
significant concentrations are found in the feces. Excretion is
depressed in renal failure. Hemodialysis removes 48–51% of
the drug in 4 h; peritoneal dialysis has little or no effect.
Increased bleeding and decreases in platelet function associated
with the methylthiotetrazole side chain are sufficiently
common to have been cited as reasons for restricting use of
the agent. Use is contraindicated in patients on anticoagulant
therapy. Uses are similar to those of group 4 cephalosporins.
It is generally less successful in the treatment of infections due
to Gram-positive organisms.
Check Digit Verification of cas no
The CAS Registry Mumber 64952-97-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,4,9,5 and 2 respectively; the second part has 2 digits, 9 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 64952-97:
(7*6)+(6*4)+(5*9)+(4*5)+(3*2)+(2*9)+(1*7)=162
162 % 10 = 2
So 64952-97-2 is a valid CAS Registry Number.
InChI:InChI=1/C20H20N6O9S/c1-25-19(22-23-24-25)36-8-10-7-35-18-20(34-2,17(33)26(18)13(10)16(31)32)21-14(28)12(15(29)30)9-3-5-11(27)6-4-9/h3-6,12,18,27H,7-8H2,1-2H3,(H,21,28)(H,29,30)(H,31,32)/t12?,18-,20+/m1/s1
64952-97-2Relevant articles and documents
A β - lactam compound carboxy and hydroxy protecting group removing method (by machine translation)
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Paragraph 0041; 0042; 0043, (2018/04/02)
The invention discloses a β - lactam compound carboxyl and hydroxyl protecting group removal method, the method is that the carboxyl and/or hydroxyl protected β - lactam compounds in the trichloro acetic acid and carbon is ion absorbent for removing protecting group and gets the role of β - lactam compound deprotected product. The method adopts the trichloro acetic acid instead of trifluoro acetic acid, trichloro acetic acid and phenol or cresol and, anisole together, can greatly reduce the consumption of the trichloroacetic acid; in addition, trichloro acetic acid in the cephalosporin into sodium salt in the follow-up process meets the volunteer fire brigade into chloroform and carbon dioxide, is easy to remove, does not exist the problem of residual of the trichloroacetic acid, the reaction yield is high, relatively few impurities; trichloro acetic acid is inexpensive and environmentally friendly, reduce the cost beneficial to industrial production. (by machine translation)
