65-31-6

Basic information

• Product Name: Nicotine ditartrate
• Synonyms: (-)-nicotinehydrogentartrate;nicotine,tartrate(1:2);nicotineacidtartrate;nicotinehydrogentartrate;nikotinbitartrat;pyridine,3-(1-methyl-2-pyrrolidinyl)-,(s)-,(r-(r*,r*))-2,3-dihydroxybutane;pyridine,3-(1-methyl-2-pyrrolidinyl)-,(s)-,(r-(r*,r*))-2,3-dihydroxybutanedi;tartratedenicotine
• CAS NO: 65-31-6
• Molecular Formula: 2C₄H₆O₆*C₁₀H₁₄N₂
• Molecular Weight: 462.41
• EINECS: 200-607-2
• Product Categories: EXLAX
• Mol File: 65-31-6.mol
• Article Data: 1

Chemical Properties

• Melting Point: 90°
• Boiling Point: 508℃(e)
• Flash Point: 101.7°C
• Appearance: white to off-white/powder
• Vapor Pressure: 0.0303mmHg at 25°C
• Storage Temp.: Desiccate at RT
• Solubility: H2O: 50 mg/mL
• Water Solubility: 1000000 mg l-1 (e)
• CAS DataBase Reference: Nicotine ditartrate(CAS DataBase Reference)
• NIST Chemistry Reference: Nicotine ditartrate(65-31-6)
• EPA Substance Registry System: Nicotine ditartrate(65-31-6)

Safety Data

• Hazard Codes: T+,N
• Statements: 26/27/28-51/53
• Safety Statements: 13-28-45-61
• RIDADR: UN 1659 6.1/PG 2
• WGK Germany: 2
• RTECS: QT0350000
• HazardClass: 6.1(a)
• PackingGroup: II
• Hazardous Substances Data: 65-31-6(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 65-31-6 differently. You can refer to the following data:
1. nicotinyl acetylchloline receptor agonist, ectoparasiticide
2. cathartic, laxative

General Description

Potent agonist of the nicotinic acetylcholine receptor. Stimulates autonomic ganglia and skeletal muscle neuromuscular junctions.

Biological Activity

Nicotinic acetylcholine receptor (nAChR) agonist (K i values are 1, > 1000, 4000 and 7130 nM at α 4 β 2, α 1 β 1 δ γ , rat α 7 and human α 7 respectively). Exhibits vasoconstrictive, hypertensive and prothrombotic activity in vivo .

Biochem/physiol Actions

Product does not compete with ATP.

Safety Profile

Poison by ingestion, intravenous, intraperitoneal, and subcutaneous routes. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx and CO. See also NICOTINE.

InChI:InChI=1/C10H14N2.C4H6O6/c1-12-7-3-5-10(12)9-4-2-6-11-8-9;5-1(3(7)8)2(6)4(9)10/h2,4,6,8,10H,3,5,7H2,1H3;1-2,5-6H,(H,7,8)(H,9,10)/t10-;/m0./s1

Upstream product

• 50-00-0 formaldehyd 
• 87-69-4 L-(+)-tartaric acid 
• 7076-23-5 (+)-nornicotine 

Relevant articles and documents

Disposition kinetics of nicotine and cotinine enantiomers in rabbits and beagle dogs

The disposition kinetics of nicotine and cotinine enantiomers was determined in rabbits. The clearance of (R)-nicotine was similar to that of (S)-nicotine, but clearance of (R)-cotinine was twice that of (S)-cotinine. Fractional conversions of both enantiomers of nicotine to cotinine were ~50%. These results suggest that in rabbits the biotransformation pathways of cotinine, but not nicotine, are influenced by stereochemistry. The disposition kinetics of nicotine enantiomers in beagle dogs was also studied. In dogs, the clearance of (R)-nicotine was slightly greater than the clearance of (S)-nicotine. Methods for the synthesis of (R)-nicotine and (R)-cotinine of high enantiomeric purity and a gas chromatographic method for determination of nicotine enantiomeric purity are described.