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| Name |
Nicotine ditartrate |
EINECS | 200-607-2 |
| CAS No. | 65-31-6 | Density | N/A |
| PSA | 246.25000 | LogP | -2.45900 |
| Solubility | 1000000mgl-1(e) | Melting Point |
89℃ |
| Formula | C10H14N2.2(C4H6O6) | Boiling Point | 508℃(e) |
| Molecular Weight | 462.411 | Flash Point | 101.7°C |
| Transport Information | N/A | Appearance | A reddish white crystalline solid. |
| Safety | Poison by ingestion, intravenous, intraperitoneal, and subcutaneous routes. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx and CO. See also NICOTINE. | Risk Codes | 26/27/28-51/53 |
| Molecular Structure |
|
Hazard Symbols | T+,N |
| Synonyms |
Tartrate de nicotine;Pyridine, 3-(1-methyl-2-pyrrolidinyl)-, (S)-, (R-(R*,R*))-2,3-dihydroxybutanedioate (1:2) (9CI);Nicotine-D-bitartrate;Nicotine dihydrogen ditartrate;NICOTINE TARTRATE (1:2);(S)-3-(1-METHYL-2-PYRROLIDINYL-PYRIDINE (R)-(R,R))-2,3-DIHYDROXYBUTANEDIOATE (1:2);(?)-NICOTINE HYDROGEN TARTRATE;NICOTINE TARTRATE (DOT);TARTRATE de NICOTINE (FRENCH);NICOTINE BI-L-(+)-TARTRATE 98.0+% T;Nikotinbitartrat [German];Nicotine bitartrate;Nicotine;Pyridine, 3- (1-methyl-2-pyrrolidinyl)-, (S)-, [R-(R*,R*)]-2, 3-dihydroxybutanedioate (1:2);Nicotine acid tartrate;(2S) 3-(1-Methyl-pyrrolidin-2-yl)-pyridine;Nicotine, tartrate (1:2);NICOTINE TARTRATE;Tartrate de nicotine [French];Nicotine hydrogen tartarate;Nicotine tartrate (VAN);(-)-Nicotine hydrogen tartrate;(2R,3R)-2,3-dihydroxybutanedioic acid; 3-(1-methylpyrrolidin-2-yl)pyridine;Nicotine tartrate [UN1659] [Poison];Pyridine, 3- (1-methyl-2-pyrrolidinyl)-, (S)-, [R-(R,R)]-2, 3-dihydroxybutanedioate (1:2);Nicotine hydrogen tartrate;54-11-5;Nicotine tartrate dihydrate;3-[(2S)-1-methylpyrrolidin-2-yl]pyridine;Pyridine, 3-(1-methyl-2-pyrrolidinyl)-, (S)-, (R-(R*,R*))-2,3-dihydroxybutanedioate (1:2); |
Nicotine ditartrate Chemical Properties
Chemistry informtion about Nicotine ditartrate(1:2) (65-31-6) is:
IUPAC Name: 2,3-dihydroxybutanedioic acid ; 3-(1-methylpyrrolidin-2-yl)pyridine ; (2R,3R)-2,3-dihydroxybutanedioic acid ; 3-(1-methylpyrrolidin-2-yl)pyridine
Synonyms: (-)-nicotinehydrogentartrate;nicotine,tartrate(1:2) ; nicotineacidtartrate ; nicotinehydrogentartrate ; nikotinbitartrat ; pyridine,3-(1-methyl-2-pyrrolidinyl)-,(s)-,(r-(r*,r*))-2,3-dihydroxybutane ; pyridine,3-(1-methyl-2-pyrrolidinyl)-,(s)-,(r-(r*,r*))-2,3-dihydroxybutanedi ; tartratedenicotine
MF: C18H26N2O12
MW: 462.41
EINECS: 200-607-2
Boiling Point: 244.4 °C at 760 mmHg
Flash Point: 101.7 °C
Enthalpy of Vaporization: 48.15 kJ/mol
Vapour Pressure: 0.0303 mmHg at 25°C
Following is the molecular structure of Nicotine ditartrate(1:2) (65-31-6) is:
Nicotine ditartrate Uses
Nicotine ditartrate(1:2) (65-31-6) can be used in smoking cessation treatment,also used in a medicine as a drug which counteracts the effect of tetanus and strychnine poisoning.
Nicotine ditartrate Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
| frog | LD50 | parenteral | 337mg/kg (337mg/kg) | | Acta Biologica et Medica Germanica. Vol. 28, Pg. 681, 1972. |
| hamster | LD50 | intraperitoneal | 125mg/kg (125mg/kg) | | Toxicology and Applied Pharmacology. Vol. 22, Pg. 324, 1972. |
| mouse | LD50 | intraperitoneal | 9100ug/kg (9.1mg/kg) | | Toxicology and Applied Pharmacology. Vol. 65, Pg. 366, 1982. |
| mouse | LD50 | intravenous | 300ug/kg (0.3mg/kg) | Behavioral: convulsions or effect on seizure thresholdbehavioral: regidity | British Journal of Pharmacology. Vol. 35, Pg. 161, 1969. |
| mouse | LD50 | oral | 65mg/kg (65mg/kg) | | Pharmacological Research Communications. Vol. 5, Pg. 341, 1973. |
| mouse | LD50 | subcutaneous | 53mg/kg (53mg/kg) | | Pharmacological Research Communications. Vol. 5, Pg. 341, 1973. |
| rat | LD50 | intraperitoneal | 83mg/kg (83mg/kg) | | Toxicology and Applied Pharmacology. Vol. 22, Pg. 324, 1972. |
| rat | LD50 | intravenous | 600mg/kg (600mg/kg) | Behavioral: convulsions or effect on seizure threshold | Pharmacological Research Communications. Vol. 5, Pg. 341, 1973. |
| rat | LD50 | oral | 65mg/kg (65mg/kg) | | Pharmacological Research Communications. Vol. 5, Pg. 341, 1973. |
| rat | LD50 | parenteral | 33500ug/kg (33.5mg/kg) | | Acta Biologica et Medica Germanica. Vol. 28, Pg. 681, 1972. |
| rat | LD50 | unreported | 30mg/kg (30mg/kg) | | Schweizerische Medizinische Wochenschrift. Vol. 91, Pg. 359, 1961. |
Nicotine ditartrate Safety Profile
Hazard codes:
T+: Very toxic.gif){kind=small}
N: Dangerous for the environment
Risk Statements:
R26/27/28: Very toxic by inhalation, in contact with skin and if swallowed.
R51/53: Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Safety Statements:
S13: Keep away from food, drink and animal foodstuffs.
S28: After contact with skin, wash immediately with plenty of soap-suds.
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S61: Avoid release to the environment. Refer to special instructions / safety data sheets.
RIDADR: UN 1659 6.1/PG 2
WGK Germany: 2
RTECS: QT0350000
HazardClass: 6.1(a)
PackingGroup: II
Hazardous Substances Data: 65-31-6(Hazardous Substances Data)
Nicotine ditartrate Specification
Appearance: a reddish white crystalline solid.
Solubility in water: very Soluble.
First Aid Measures:
Ingestion: get medical aid. Do not induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation: remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Skin: get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Eyes: flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Handling and Storage:
Storage: store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Poison room locked.
Handling: wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.
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