65490-09-7Relevant articles and documents
Neuroregenerative Potential of Prenyl- And Pyranochalcones: A Structure-Activity Study
Aigner, Ludwig,Bieler, Lara,Couillard-Despres, Sebastien,Priglinger, Eleni,Riepl, Herbert M.,Urmann, Corinna
supporting information, p. 2675 - 2682 (2021/10/12)
Loss of neuronal tissue is a hallmark of age-related neurodegenerative diseases. Since adult neurogenesis has been confirmed in the human brain, great interest has arisen in substances stimulating the endogenous neuronal regeneration mechanism based on ad
Synthesis of rottlerone analogues and evaluation of their -glucosidase and DPP-4 dual inhibitory and glucose consumption-promoting activity
Dodd, Robert H.,Lu, Kui,Sun, Hua,Wang, Haibo,Wu, Yan,Yan, Zhihong,Yu, Peng,Zhang, Yinan,Zhao, Xue
, (2021/06/12)
Our previous study found that desmethylxanthohumol (1) inhibited α-glucosidase in vitro. Recently, further investigations revealed that dehydrocyclodesmethylxanthohumol (2) and its dimer analogue rottlerone (3) exhibited more potent α-glucosidase inhibito
An Efficient Regioselective Synthesis of 8-Formylhomoisoflavonoids with Neuroprotective Activity by Enhancing Autophagy
Li, Jie,Yang, Fan,Zeng, Lin-Wei,Zhang, Fang-Min,Zhou, Chang-Xin,Gan, Li-She
, p. 1385 - 1391 (2021/04/12)
6-Formylisoophiopogonone B (7a) and 8-formylophiopogonone B (7b), two natural products isolated fromOphiopogonjaponicus, represent a subgroup of rare 6/8-formyl/methyl-homoisoflavonoid skeletons. Herein we report an efficient method for the synthesis of these formyl/methyl-homoisoflavonoids. The synthesized compounds were evaluated for their neuroprotective effects on the MPP+-induced SH-SY5Y cell injury model and showed marked activity. Exploration of the neuroprotective mechanisms of compound7bled to an increased expression of autophagy marker LC3-II and down-regulation of autophagy substrate p62/SQSTM1. Molecular docking studies showed that7bmay prevent the inhibition of the classic PI3K-AKT-mTOR signaling pathway by interfering with the human HSP90AA1.