656836-79-2

Basic information

• Product Name: 14-(4-hydroxy-3-methoxyphenyl)-3,11-dihydroxy-2,12-dimethoxy-8,9-dihydro-6H-chromeno[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one
• Synonyms: 14-(4-hydroxy-3-methoxyphenyl)-3,11-dihydroxy-2,12-dimethoxy-8,9-dihydro-6H-chromeno[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one
• CAS NO: 656836-79-2
• Molecular Weight: 501.493
• Mol File: 656836-79-2.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 14-(4-hydroxy-3-methoxyphenyl)-3,11-dihydroxy-2,12-dimethoxy-8,9-dihydro-6H-chromeno[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one(CAS DataBase Reference)
• NIST Chemistry Reference: 14-(4-hydroxy-3-methoxyphenyl)-3,11-dihydroxy-2,12-dimethoxy-8,9-dihydro-6H-chromeno[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one(656836-79-2)
• EPA Substance Registry System: 14-(4-hydroxy-3-methoxyphenyl)-3,11-dihydroxy-2,12-dimethoxy-8,9-dihydro-6H-chromeno[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one(656836-79-2)

Safety Data

• Hazardous Substances Data: 656836-79-2(Hazardous Substances Data)

Upstream product

• 190278-32-1 3,10-Bis-benzyloxy-13-(4-benzyloxy-3-methoxy-phenyl)-2,11-dimethoxy-5-oxa-6b-aza-dibenzo[a,i]fluoren-6-one 
• 29973-94-2 6-(benzyloxy)-1-(4-(benzyloxy)-3-methoxybenzyl)-7-methoxyIsoquinoline 
• 35320-04-8 2-(4-(benzyloxy)-3-methoxyphenyl)-N-(2-(3-(benzyloxy)-4-methoxyphenyl)-2-methoxyethyl)acetamide 
• 123438-48-2 6-(benzyloxy)-7-methoxy-1-methylisoquinoline 
• 29973-93-1 2-(3-(benzyloxy)-4-methoxyphenyl)-2-methoxyethan-1-amine 
• 29973-92-0 2-(benzyloxy)-1-methoxy-4-(1-methoxy-2-nitroethyl) Benzene 
• 79418-71-6 4-(benzyloxy)-2-hydroxy-5-methoxybenzaldehyde 
• 51061-83-7 2,4-dihydroxy-5-methoxybenzaldehyde 
• 19009-24-6 3-hydroxy-4-methoxyphenyl formate 
• 7298-21-7 1-(2,4-dihydroxy-5-methoxyphenyl)ethan-1-one 

Downstream Products

• 660397-19-3 2-tert-butoxycarbonylamino-propionic acid 10-(2-tert-butoxycarbonylamino-propionyloxy)-13-[4-(2-tert-butoxycarbonylamino-propionyloxy)-3-methoxy-phenyl]-2,11-dimethoxy-6-oxo-7,8-dihydro-6H-5-oxa-6b-aza-dibenzo[a,i]fluoren-3-yl ester 
• 660397-06-8 C₆₁H₇₈N₄O₁₇ 
• 660395-92-6 2-tert-butoxycarbonylamino-3-methyl-butyric acid 10-(2-tert-butoxycarbonylamino-3-methyl-butyryloxy)-13-[4-(2-tert-butoxycarbonylamino-3-methyl-butyryloxy)-3-methoxy-phenyl]-2,11-dimethoxy-6-oxo-6H-5-oxa-6b-aza-dibenzo[a,i]fluoren-3-yl ester 
• 660395-97-1 2-tert-butoxycarbonylamino-propionic acid 10-(2-tert-butoxycarbonylamino-propionyloxy)-13-[4-(2-tert-butoxycarbonylamino-propionyloxy)-3-methoxy-phenyl]-2,11-dimethoxy-6-oxo-6H-5-oxa-6b-aza-dibenzo[a,i]fluoren-3-yl ester 
• 97614-65-8 lamellarin D 
• 97633-82-4 14-(4-acetoxy-3-methoxyphenyl)-3,11-diacetoxy-2,12-dimethoxy-6H-chromeno[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one 
• 660396-68-9 14-(4-acetoxy-3-methoxyphenyl)-3,11-diacetoxy-2,12-dimethoxy-8,9-dihydro-6H-chromeno[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one 
• 660395-51-7 3-phenyl-propionic acid 2,11-dimethoxy-13-[3-methoxy-4-(3-phenyl-propionyloxy)-phenyl]-6-oxo-10-(3-phenyl-propionyloxy)-7,8-dihydro-6H-5-oxa-6b-aza-dibenzo[a,i]fluoren-3-yl ester 
• 660395-69-7 methanesulfonic acid 10-methanesulfonyloxy-13-(4-methanesulfonyloxy-3-methoxy-phenyl)-2,11-dimethoxy-6-oxo-7,8-dihydro-6H-5-oxa-6b-aza-dibenzo[a,i]fluoren-3-yl ester 
• 660396-82-7 C₇₀H₇₄N₄O₁₇ 
• 660396-99-6 C₄₉H₂₃F₁₂NO₁₁ 
• 660397-13-7 (4-fluoro-phenylsulfanyl)-acetic acid 10-[(4-fluoro-phenylsulfanyl)-acetoxy]-13-{4-[(4-fluoro-phenylsulfanyl)-acetoxy]-3-methoxy-phenyl}-2,11-dimethoxy-6-oxo-7,8-dihydro-6H-5-oxa-6b-aza-dibenzo[a,i]fluoren-3-yl ester 

Relevant articles and documents

METHOD FOR PRODUCING LAMELLARIN AND DERIVATIVE THEREOF

The present application discloses a method for producing lamellarin and a derivative thereof, which is able to greatly shorten the synthesis path of the lamellarin and the derivative thereof, and to improve the yield of the lamellarin and the derivative t

Design and total synthesis of Mannich derivatives of marine natural product lamellarin D as cytotoxic agents

Enlightened by the modification route from Camptothecin (CPT) to Topotecan and based on classical drug design theory, a series of Mannich derivatives of lamellarin D were designed and synthesized in 26-27 steps starting from vanillin and isovanilin. All synthesized compounds were then biologically evaluated for their in vitro anti-cancer activities and Topo I inhibitory activities. The results showed that most target compounds exhibited Topo I inhibitory activities in equivalent level with that of lamellarin D. Compound SL-9 exhibited better Topo I inhibitory activity than that of lamellarin D. Compounds SL-2, SL-3, SL-4, SL-5 and SL-11 exhibited better anti-proliferative activity against HT-29 cells than that of lamellarin D.

ANTITUMORAL ANALOGS OF LAMELLARINS

New lamellarins are provided of the general formula III wherein X is selected from the group consisting of N, O and S; wherein R1, R2, R3, R4, R5, R6, R7, R8 and Rsub