6627-78-7

Basic information

• Product Name: 1-BROMO-2-METHYLNAPHTHALENE
• Synonyms: 4-BROMO-1-METHYLNAPHTHALENE;1-BROMO-4-METHYLNAPHTHALENE;1-BROMO-2-METHYLNAPHTHALENE;4-Methyl-1-bromonaphthalene;1-Methyl-4-bromonaphthalene;Einecs 229-599-9;NSC 60231;1-BroMo-4-Methylnaphthalene 98%
• CAS NO: 6627-78-7
• Molecular Formula: C₁₁H₉Br
• Molecular Weight: 221.09
• EINECS: 219-966-1
• Product Categories: Naphthalene derivatives;Aryl;C9 to C12;Halogenated Hydrocarbons
• Mol File: 6627-78-7.mol
• Article Data: 23

Chemical Properties

• Melting Point: 127-128℃
• Boiling Point: 296 °C(lit.)
• Flash Point: >230 °F
• Appearance: /
• Density: 1.419 g/mL at 25 °C(lit.)
• Refractive Index: n20/D 1.651(lit.)
• Storage Temp.: Room temperature.
• Water Solubility: Sparingly Soluble in water. (1.9E-3 g/L) (25°C).
• CAS DataBase Reference: 1-BROMO-2-METHYLNAPHTHALENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BROMO-2-METHYLNAPHTHALENE(6627-78-7)
• EPA Substance Registry System: 1-BROMO-2-METHYLNAPHTHALENE(6627-78-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 6627-78-7(Hazardous Substances Data)

Usage

General Description

1-Bromo-2-methylnaphthalene is a chemical compound that contains a naphthalene core with a bromine atom and a methyl group attached at specific positions. It is used as a building block for the synthesis of various organic compounds, and is commonly employed as a reagent in organic chemistry reactions. Due to its unique structure, it exhibits interesting properties such as steric hindrance and electron delocalization, making it useful in the formation of complex molecular structures. The compound is also a potential candidate for use in research and development of new materials and pharmaceuticals due to its versatile chemical reactivity and potential biological activity. However, it is important to handle this chemical with caution as it is a hazardous material, with potential health and environmental risks if not properly handled and disposed of.

InChI:InChI=1/C17H11BrFN3O3/c18-10-1-7-13(8-2-10)22-16(24)14(15(23)21-17(22)25)9-20-12-5-3-11(19)4-6-12/h1-9,20H,(H,21,23,25)/b14-9+

Upstream product

• 90-12-0 1-Methylnaphthalene 
• 7732-18-5 water 
• 7726-95-6 bromine 
• 6140-10-9 4-methyl-naphthalene-1-sulfonic acid ; potassium-salt 
• 63279-58-3 1-iodo-4-bromo-naphthalene 
• 75-16-1 methylmagnesium bromide 
• 83-53-4 1,4-dibromonaphthalene 
• 74-88-4 methyl iodide 
• 3163-27-7 2-(bromomethyl)naphthalene 
• 90-11-9 1-Bromonaphthalene 
• 7601-90-3 perchloric acid 
• 14927-61-8 4-methyl-1-naphthylsulphonic acid 
• 75-15-0 carbon disulfide 
• 64-19-7 acetic acid 

Downstream Products

• 16650-55-8 4-bromonaphthalene-1-carboxylic acid 
• 571-58-4 1,4-dimethylnaphthalene 
• 71235-72-8 3-methyl-1-cyanonaphthalene 
• 79996-99-9 1-bromo-4-bromomethyl-naphthalene 
• 52718-76-0 1-n-butyl-4-methylnaphthalene 
• 4488-40-8 4-Methyl-1-naphthoic acid 
• 103986-53-4 4-methyl-1-naphthylboronic acid 
• 1050521-36-2 N-(4-methoxyphenyl)-4-methyl-N-(4-methylnaphthalen-1-yl)naphthalen-1-amine 
• 13280-69-8 1-methyl-4-phenylnaphthalene 
• 35615-97-5 4-bromo-naphthalene-1-carboxylic acid methyl ester 
• 627526-50-5 4,4,5,5-tetramethyl-2-(1-methylnaphthalen-4-yl)-1,3,2-dioxaborolane 
• 4523-45-9 1-amino-4-methylnaphthalene 
• 4523-46-0 4-methyl-2-naphthalenamine 
• 35187-29-2 2-(4-Methylnaphthoyl)benzoic acid 

Relevant articles and documents

CRYSTAL FORM OF URATE TRANSPORTER 1 INHIBITOR AND PREPARATION METHOD AND USE THEREOF

The present invention provides a crystal form of urate transporter 1 inhibitor and a preparation method and use thereof. The crystal form is characterized by a stable state of appearance and a capability of further improving the purity and storage stability of the compound, etc., and suitable as a pharmaceutical raw material.

METHOD FOR PREPARING URATE TRANSPORTER 1 INHIBITOR

Provided is a method for preparing a URAT1 inhibitor, 2-((5-bromo-4-((4-bromonaphthalen-1-yl)methyl)-4H-1,2,4-triazol-3-yl)thio) acetic acid represented by the following formula ZXS-BR, the reaction equation of which being shown as follows. Compared with the prior art, the preparation method provided by the present application is of low cost, ease of handling, ease of quality control, and applicable to industrialization.