66309-83-9Relevant articles and documents
Synthesis method of 2,6-dimethyl-1-indanone
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Paragraph 0010; 0035-0070, (2020/11/22)
The invention belongs to the field of chemical synthesis, and relates to a synthesis method of 2,6-dimethyl-1-indanone, which comprises the following steps: by using m-methylbenzoyl chloride and propylene as raw materials, carrying out Friedel-Crafts acylation under the catalysis of aluminum trichloride, and carrying out Friedel-Crafts alkylation reaction to synthesize the target product 2,6-dimethyl-1-indanone. The method is short in synthetic route and high in total yield, the aluminum-containing wastewater generated in the process can be used for preparing a flocculating agent, the whole route is clean and environmentally friendly, environmental pollution is small, and the method is suitable for industrial production.
B(C6F5)3-Catalyzed Highly Stereoselective Hydrogenation of Unfunctionalized Tetrasubstituted Olefins
Dai, Yun,Feng, Xiangqing,Du, Haifeng
supporting information, p. 6884 - 6887 (2019/10/02)
A metal-free hydrogenation of unfunctionalized tetrasubstituted olefins were successfully realized using a combination of B(C6F5)3 and Ph2NMe catalyst. The corresponding products were afforded in 58-98% yields with up to >99:1 cis/trans selectivity.
Synthesis and SAR study of modulators inhibiting tRXRα-dependent AKT activation
Wang, Zhi-Gang,Chen, Liqun,Chen, Jiebo,Zheng, Jian-Feng,Gao, Weiwei,Zeng, Zhiping,Zhou, Hu,Zhang, Xiao-Kun,Huang, Pei-Qiang,Su, Ying
, p. 632 - 648 (2013/05/09)
RXRα represents an intriguing and unique target for pharmacologic interventions. We recently showed that Sulindac and a designed analog could bind to RXRα and modulate its biological activity, including inhibition of the interaction of an N-terminally truncated RXRα (tRXRα) with the p85α regulatory subunit of phosphatidylinositol-3-OH kinase (PI3K). Here we report the synthesis, testing and SAR of a series of novel analogs of Sulindac as potential modulators for inhibiting tRXRα-dependent AKT activation. A new compound 30 was identified to have improved biological activity.