6642-31-5Relevant articles and documents
Spectrophotometric investigation of 5-nitroso-6-aminouracil and its methyl derivative in methanol by selective complexation with bivalent metal ions
Das, Subrata,Hussain, Sahid,Kumar, Brajesh,Kumar, Pramanand,Sugunakara Rao, Mugada
, (2020/07/20)
6-Amino-5-nitrosouracils are synthesized by the condensation reaction of urea or N,N′-dimethyl urea, cyanoacetic acid and acetic anhydride followed by nitrosation reaction with sodium nitrite. The synthesized compounds are characterized by various spectroscopic techniques like FTIR, NMR, single crystal XRD, and UV–vis absorption spectroscopy. From a single-crystal X-ray crystallography study of DANU, it is found that the compound is crystalline with one water molecule. The binding properties of both compounds with various metal ions are studied using UV–vis spectroscopy, where ANU shows a colour change from colourless to yellow colour-forming complex with cobalt metal ion. While DANU shows a colour change from colourless to dark yellow forming complex with copper and nickel cation, respectively. These compounds showed the job's plots with Cu2+, Ni2+, and Co2+ in various stoichiometric ratios to form the respective metal complex. The association/binding constant (Ka) values are calculated by plotting Benesi–Hilderbrand plots of ANU with Co2+ ion and is found to be 9.524 × 102. Whereas, DANU with Cu2+, Ni2+ are found to be 3.956 × 103, 2.041 × 103, respectively. These cations may be used in metal ions complexation for the respective ligand. The LOD values for ANU-Co2+, DANU-Cu2+ & DANU-Ni2+ are obtained as 33.9428 μM, 93.8082 μM and 48.396 μM, respectively, whereas the LOQ values are found as 102.857 μM, 284.2675 μM and 146.653 μM, respectively.
Iodine/persulfate-promoted site-selective direct thiolation of quinolones and uracils
Beukeaw, Danupat,Noikham, Medena,Yotphan, Sirilata
supporting information, (2019/09/03)
A simple and general method for direct thiolation of 4-quinolones with disulfides or thiols under I2/K2S2O8 system has been developed. Under the optimal conditions, the C–S bond coupling can take place effectively with good to decent yields and excellent regioselectivity of the S-linked products. The established metal-free site-selective approach was also applicable to transform a range of uracil substrates to the thio-substituted products under mild conditions. Further transformation to the sulfone derivatives can be conveniently performed in one-pot. These easy-to-handle protocols represent a useful and interesting synthetic alternative with good substrate scope and functional group compatibility.
Selective Inhibitors of a Human Prolyl Hydroxylase (OGFOD1) Involved in Ribosomal Decoding
Thinnes, Cyrille C.,Lohans, Christopher T.,Abboud, Martine I.,Yeh, Tzu-Lan,Tumber, Anthony,Nowak, Rados?aw P.,Attwood, Martin,Cockman, Matthew E.,Oppermann, Udo,Loenarz, Christoph,Schofield, Christopher J.
supporting information, p. 2019 - 2024 (2019/01/11)
Human prolyl hydroxylases are involved in the modification of transcription factors, procollagen, and ribosomal proteins, and are current medicinal chemistry targets. To date, there are few reports on inhibitors selective for the different types of prolyl hydroxylases. We report a structurally informed template-based strategy for the development of inhibitors selective for the human ribosomal prolyl hydroxylase OGFOD1. These inhibitors did not target the other human oxygenases tested, including the structurally similar hypoxia-inducible transcription factor prolyl hydroxylase, PHD2.