Basic Information | Post buying leads | Suppliers | Cas Database |
N,N'-Dimethylurea
acetic anhydride
cyanoacetic acid
6-Amino-1,3-dimethylbarbituric acid
Conditions | Yield |
---|---|
at 60℃; for 3h; | 96% |
4-Amino-2,6-dihydroxypyrimidine
methyl iodide
6-Amino-1,3-dimethylbarbituric acid
Conditions | Yield |
---|---|
Stage #1: 4-Amino-2,6-dihydroxypyrimidine With potassium hydroxide In ethanol for 0.666667h; Heating; Stage #2: methyl iodide In ethanol for 8h; Heating; | 90% |
With sodium hydroxide | |
Stage #1: 4-Amino-2,6-dihydroxypyrimidine With sodium hydride In dimethyl sulfoxide for 13h; Stage #2: methyl iodide In dimethyl sulfoxide for 0.75h; Time; |
6-azido-1,3-dimethylpyrimidine-2,4(1H,3H)-dione
6-Amino-1,3-dimethylbarbituric acid
Conditions | Yield |
---|---|
In tetralin at 150℃; for 0.0833333h; | 90% |
With hydrogen; palladium on activated charcoal In methanol for 1h; Ambient temperature; | 85% |
Multi-step reaction with 2 steps 1: 94 percent / toluene / 0.5 h / Heating 2: 62 percent / aq. AcOH, CF3COOH / 6 h / Heating View Scheme |
Conditions | Yield |
---|---|
Stage #1: N,N'-Dimethylurea; cyanoacetic acid With acetic anhydride at 60℃; for 0.166667h; microwave irradiation; Stage #2: With sodium hydroxide In ethanol at 20℃; | 80% |
With sodium ethanolate for 4h; Reflux; | 80% |
In acetic anhydride at 60℃; for 3h; Inert atmosphere; | 79% |
1-(2-cyanoacetyl)-1,3-dimethyl-urea
6-Amino-1,3-dimethylbarbituric acid
Conditions | Yield |
---|---|
With chloro-trimethyl-silane; 1,1,1,3,3,3-hexamethyl-disilazane for 24h; Cyclization; Heating; | 79% |
With sodium hydroxide | 70% |
With potassium acetate |
1,3-dimethyl-2,4-dioxo-6-<(triphenylphosphoranylidene)amino>-1,2,3,4-tetrahydropyrimidine
6-Amino-1,3-dimethylbarbituric acid
Conditions | Yield |
---|---|
With acetic acid; trifluoroacetic acid for 6h; Heating; | 62% |
6-amino-1,3-dimethyl-5-formyluracil
edaravone
A
6-Amino-1,3-dimethylbarbituric acid
B
1-phenyl-3-methyl-4-(1-phenyl-3-methyl-5-oxo-4-pyrazolylidene)methylene-5-pyrazolone
Conditions | Yield |
---|---|
With piperidine In ethanol at 20℃; for 1h; | A 60% B n/a |
5,7-Dimethylpyrimido<4.5-e>-1,2,4-triazinedione, isofervenulin
A
6-Amino-1,3-dimethylbarbituric acid
B
1,3-dimethyl-5-phenyl-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidine-2,4-dione
Conditions | Yield |
---|---|
With diethylamine; acetophenone at 100 - 110℃; for 3h; | A 19% B 56% |
5,7-Dimethylpyrimido<4.5-e>-1,2,4-triazinedione, isofervenulin
acetophenone
A
6-Amino-1,3-dimethylbarbituric acid
B
1,3-dimethyl-5-phenyl-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidine-2,4-dione
Conditions | Yield |
---|---|
With diethylamine at 100 - 110℃; for 3h; | A 19% B 56% |
Conditions | Yield |
---|---|
With sodium methylate In methanol for 5h; Heating; | 36% |
IUPAC Name: 6-Amino-1,3-dimethylpyrimidine-2,4-dione
Molecular Formula: C6H9N3O2
Molecular Weight: 155.16 g/mol
Canonical SMILES: c1(n(c(N)cc(n1C)=O)C)=O
InChI: InChI=1/C6H9N3O2/c1-8-4(7)3-5(10)9(2)6(8)11/h3H,7H2,1-2H3
EINECS: 229-662-0
Classification Code: Drug / Therapeutic Agent; TSCA Flag P
Product Categories: Amines;Building Blocks; Heterocyclic Building Blocks; Pyrimidines
XLogP3-AA: -1.1
H-Bond Donor: 1
H-Bond Acceptor: 3
Tautomer Count: 3
Exact Mass: 155.069477
MonoIsotopic Mass: 155.069477
Topological Polar Surface Area: 66.6
Heavy Atom Count: 11
Complexity: 246
Index of Refraction: 1.55
Molar Refractivity: 38.4 cm3
Molar Volume: 120.4 cm3
Polarizability: 15.22×10-24 cm3
Surface Tension: 48.2 dyne/cm
Density: 1.288 g/cm3
Flash Point: 100.8 °C
Enthalpy of Vaporization: 48.01 kJ/mol
Boiling Point: 243.1 °C at 760 mmHg
Melting Point: 295 °C (dec.)(lit.)
Vapour Pressure of 6-Amino-1,3-dimethyluracil (CAS NO.6642-31-5): 0.0328 mmHg at 25 °C
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intravenous | 56mg/kg (56mg/kg) | U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#04375, | |
mouse | LD50 | oral | > 1gm/kg (1000mg/kg) | Farmaco. Vol. 45, Pg. 223, 1990. |
Hazard Codes: Xn
Risk Statements: 22-36/37/38
R22: Harmful if swallowed.
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 22-26-36/37/39
S22: Do not breathe dust.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.
WGK Germany of 6-Amino-1,3-dimethyluracil (CAS NO.6642-31-5): 1
6-Amino-1,3-dimethyluracil (CAS NO.6642-31-5), its Synonyms are 2,4(1H,3H)-Pyrimidinedione, 6-amino-1,3-dimethyl- ; Uracil, 6-amino-1,3-dimethyl- ; 6-Amino-1,3-dimethyl-2,4(1H,3H)-pyrimidinedione .