667940-07-0

Basic information

• Product Name: 1-Piperidinecarboxylic acid, 3-[(acetyloxy)methyl]-5-[(2R)-1,2,3,6-tetrahydro-6-oxo-2-pyridinyl]-, phenylmethyl ester, (3S,5R)-
• CAS NO: 667940-07-0
• Molecular Formula: C21H26N2O5
• Molecular Weight: 386.448
• Mol File: 667940-07-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-Piperidinecarboxylic acid, 3-[(acetyloxy)methyl]-5-[(2R)-1,2,3,6-tetrahydro-6-oxo-2-pyridinyl]-, phenylmethyl ester, (3S,5R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Piperidinecarboxylic acid, 3-[(acetyloxy)methyl]-5-[(2R)-1,2,3,6-tetrahydro-6-oxo-2-pyridinyl]-, phenylmethyl ester, (3S,5R)-(667940-07-0)
• EPA Substance Registry System: 1-Piperidinecarboxylic acid, 3-[(acetyloxy)methyl]-5-[(2R)-1,2,3,6-tetrahydro-6-oxo-2-pyridinyl]-, phenylmethyl ester, (3S,5R)-(667940-07-0)

Safety Data

• Hazardous Substances Data: 667940-07-0(Hazardous Substances Data)

Upstream product

• 667940-10-5 (3S,5R,1'S)-(+)-3-acetoxymethyl-5-(1'-methanesulfonyloxybut-3'-enyl)-1-piperidine-1-carboxylic acid benzyl ester 
• 667940-18-3 (3S,5R)-3-Acetoxymethyl-5-((R)-1-amino-but-3-enyl)-piperidine-1-carboxylic acid benzyl ester 
• 667940-11-6 (3S,5R,1'R)-(-)-3-acetoxymethyl-5-(1'-azidobut-3'-enyl)-1-piperidine-1-carboxylic acid benzyl ester 
• 667940-16-1 (3S,5R,1'S)-(-)-3-acetoxymethyl-5-(1'-hydroxybut-3'-enyl)-1-piperidine-1-carboxylic acid benzyl ester 
• 206761-38-8 (3S,5R)-3-acetoxymethyl-5-hydroxymethylpiperidine-1-carboxylic acid benzyl ester 
• 206554-22-5 (3S,5R)-(+)-3-acetoxymethyl-5-formyl-1-piperidine-1-carbvoxylic acid benzyl ester 
• 667940-08-1 (3S,5R,1'R)-(+)-3-acetoxymethyl-5-(1'-acryloylaminobut-3'-enyl)-1-piperidine-1-carboxylic acid benzyl ester 

Downstream Products

• 667940-12-7 (2R,3'R,5'S)-(+)-5-hydroxymethyl-6-oxo-1,2,3,6,3',4',5',6'-octahydro-2'H-[2,3']-bipyridinyl-1'-carboxylic acid benzyl ester 
• 485-35-8 cytisine 
• 667940-15-0 (6R,7R,9R)-(-)-N-benzyloxycarbonyl-cytisine 
• 667940-14-9 (6R,7R,9R)-(+)-N-benzyloxycarbonyl-5,6-dihydro-cytisine 
• 667940-13-8 (2R,3'R,5'S)-(+)-5-methanesulfonyloxymethyl-6-oxo-1,2,3,6,3',4',5',6'-octahydro-2'H-[2,3']-bipyridinyl-1'-carboxylic acid benzyl ester 

Relevant articles and documents

Total Enantioselective Synthesis of (-)-Cytisine

(Equation presented) The first total enantiosynthesis of the biologically active alkaloid (-)-cytisine is reported, featuring a ruthenium-catalyzed RCM reaction as the key step. The approach relies on readily available cis-piperidine-3,5-dimethanol monoacetate as the chiral building block, and it is suited for achieving the target compound in both enantiomeric forms.