667940-08-1Relevant articles and documents
Total Enantioselective Synthesis of (-)-Cytisine
Danieli, Bruno,Lesma, Giordano,Passarella, Daniele,Sacchetti, Alessandro,Silvani, Alessandra,Virdis, Andrea
, p. 493 - 496 (2007/10/03)
(Equation presented) The first total enantiosynthesis of the biologically active alkaloid (-)-cytisine is reported, featuring a ruthenium-catalyzed RCM reaction as the key step. The approach relies on readily available cis-piperidine-3,5-dimethanol monoacetate as the chiral building block, and it is suited for achieving the target compound in both enantiomeric forms.