669077-49-0 Usage
Description
AG035029, also known as NSC 90724, is a chemical compound identified as a potential anticancer agent. It has demonstrated potent cytotoxic effects against various cancer cell lines, including leukemia, melanoma, and renal cancer. AG035029 induces apoptosis in cancer cells by disrupting the mitochondrial membrane potential and activating caspase enzymes. It also inhibits the growth of tumor xenografts in animal models. Due to its potent anticancer activity and ability to selectively target cancer cells while sparing normal cells, AG035029 is a promising candidate for further development as a novel anticancer drug.
Uses
Used in Pharmaceutical Industry:
AG035029 is used as a potential anticancer agent for its potent cytotoxic effects against a wide variety of cancer cell lines. It is particularly effective in inducing apoptosis in cancer cells by disrupting the mitochondrial membrane potential and activating caspase enzymes.
Used in Cancer Research:
AG035029 is used in cancer research to study its mechanism of action and its potential as a novel anticancer drug. It provides valuable insights into the development of targeted therapies and the understanding of cancer cell biology.
Used in Drug Development:
AG035029 is used in drug development as a promising candidate for further research and development. Its ability to selectively target cancer cells while sparing normal cells makes it an attractive option for the development of new anticancer drugs.
Used in Tumor Xenograft Models:
AG035029 is used in tumor xenograft models to study its efficacy in inhibiting the growth of tumors in animal models. This helps in evaluating its potential as a therapeutic agent for cancer treatment.
Check Digit Verification of cas no
The CAS Registry Mumber 669077-49-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,6,9,0,7 and 7 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 669077-49:
(8*6)+(7*6)+(6*9)+(5*0)+(4*7)+(3*7)+(2*4)+(1*9)=210
210 % 10 = 0
So 669077-49-0 is a valid CAS Registry Number.
669077-49-0Relevant articles and documents
Process development and scale-up of AG035029
Saenz, James,Mitchell, Mark,Bahmanyar, Sami,Stankovic, Nebojsa,Perry, Michael,Craig-Woods, Bridgette,Kline, Billie,Yu, Shu,Albizati, Kim
, p. 30 - 38 (2012/12/26)
A practical process for the synthesis of PPARγ agonist AG035029 was developed which involved six steps along the longest linear path. The process development utilized automated technology and computational chemistry extensively to accelerate the speed of
