66910-71-2Relevant articles and documents
Design and synthesis of anti-MRSA benzimidazolylbenzenesulfonamides. QSAR studies for prediction of antibacterial activity
Gonzalez-Chavez, Marco Martin,Mendez, Francisco,Martinez, Roberto,Perez-Gonzalez, Cuauhtemoc,Martinez-Gutierrez, Fidel
experimental part, p. 175 - 189 (2011/04/22)
A series of benzimidazolylbenzenesulfonamide compounds containing electronreleasing and electron-withdrawing substituents were synthesized and tested for their in vitro antibacterial activity. Two BZS compounds showed strong antibacterial activity against methicillin-resistant Staphylococcus aureus and Bacillus subtilis. Quantitative studies of their structure-activity relationship using a simple linear regression analysis were applied to explore the correlation between the biological activity and the charges on acidic hydrogen atoms in the synthesized compounds.