66981-73-5

Basic information

• Product Name: Tianeptine
• Synonyms: TIANEPTINE;7-[(3-chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-yl)-amino]heptanoic acid s,s-dioxide;7-[(3-CHLORO-6,11-DIHYDRO-6-METHYL-DIBENZO[C,F][1,2]THIAZEPINE-11-YL)AMINO]HEPTANOIC ACID S,S DIOXIDE;Tianeptineacid;COAXIL;7-[(3-Chloro-6，11-dihydro-6-methyldibenzo[c，f][1，2]thiazepin-11-y1)amino]heptanoic acid S，S-dioxide;30123-17-2 (Mono-hydrochloride salt);Brn 1232295
• CAS NO: 66981-73-5
• Molecular Formula: C21H25ClN2O4S
• Molecular Weight: 436.95
• EINECS: 250-059-3
• Product Categories: Heterocyclic Compounds;Intermediates & Fine Chemicals;Pharmaceuticals;Tianeptine Intermediates;API;Tianeptine
• Mol File: 66981-73-5.mol
• Article Data: 4

Chemical Properties

• Melting Point: 129-131°C
• Boiling Point: 609.2 °C at 760 mmHg
• Flash Point: 322.2 °C
• Appearance: white solid
• Density: 1.38 g/cm³
• Vapor Pressure: 1.08E-15mmHg at 25°C
• Refractive Index: 1.639
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility: Freely soluble in water, in methanol and in methylene chloride.
• CAS DataBase Reference: Tianeptine(CAS DataBase Reference)
• NIST Chemistry Reference: Tianeptine(66981-73-5)
• EPA Substance Registry System: Tianeptine(66981-73-5)

Safety Data

• RIDADR: 3249
• HazardClass: 6.1(b)
• PackingGroup: III
• Hazardous Substances Data: 66981-73-5(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Originator

Stablon,Servier,France,1983

Uses

Different sources of media describe the Uses of 66981-73-5 differently. You can refer to the following data:
1. Tianeptine is used in the treatment of reactive and neurotic depression, as well as in the treatment of anxious states.
2. Tricyclic compound with psychostimulant, anti-ulcer and anti-emetic properties. Antidepressant

Therapeutic Function

Antidepressant

InChI:InChI=1/C21H25ClN2O4S/c1-24-18-9-6-5-8-16(18)21(23-13-7-3-2-4-10-20(25)26)17-12-11-15(22)14-19(17)29(24,27)28/h5-6,8-9,11-12,14,21,23H,2-4,7,10,13H2,1H3,(H,25,26)

Upstream product

• 1231718-21-0 7-(((11RS)-3-chloro-6-methyl-6,11-dihydro-dibenzo[c,f][1,2]thiazepin-11-yl)amino)heptanenitrile S,S-dioxide 
• 26638-66-4 5,8-dichloro-10,10-dioxo-11-methyl-5,11-dihydrodibenzo<1,2>thiazepine 
• 26723-60-4 5-hydroxy-8-chloro-10,10-dioxo-11-methyl-5,11-dihydrodibenzo<1,2>thiazepine 
• 66981-77-9 ethyl 7-((3-chloro-6-methyl-5,5-dioxido-6,11-dihydrodibenzo[c,f][1,2]thiazepin-11-yl)amino)heptanoate 
• 1117-66-4 7-aminoheptanoic acid ethyl ester 
• 26638-53-9 8-chloro-10,10-dioxo-11-methyl-5,11-dihydrodibenzo<1,2>thiazepin-5-one 

Downstream Products

• 66981-77-9 ethyl 7-((3-chloro-6-methyl-5,5-dioxido-6,11-dihydrodibenzo[c,f][1,2]thiazepin-11-yl)amino)heptanoate 
• 1224690-86-1 7-[(3-chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-yl)amino]heptanoic acid S,S-dioxide tosylate 

Relevant articles and documents

A process for preparing 3,11-Dichloro-6-methyl -6,11-dihydrodibenzo[c,f][1,2]thiazepine 5,5-dioxide

The present invention relates to a method for preparing 3,11-dichloro-6-methyl-6,11-dihydrodibenzo[c,f][1,2]thiazepine 5,5-dioxide. More particularly, the present invention relates to a method for preparing high-purity 3,11-dichloro-6-methyl-6,11-dihydrodibenzo[c,f][1,2]thiazepine 5,5-dioxide at a high yield under safe atmosphere through a quantitative reaction without introduction of an excessive amount of hydrogen chloride gas from the outside by substituting the hydroxyl group of 3-chloro-6-methyl-6,11-dihydrodibenzo[c,f][1,2]thiazepine-11-ol 5,5-dioxide as a starting material with a chloride group by means of hydrogen chloride gas generated in situ under the environment of acetyl chloride and the same equivalent of alcohol.

NOVEL PROCESS FOR THE PREPARATION OF 7-((3-CHLORO-6-METHYL-5,5-DIOXO-6,11-DIHYDRODIBENZO(C,F)(1,2) THIAZEPIN-11-YL)AMINO)HEPTANOATE

The present invention relates to a novel process for the preparation of sodium 7-((3-Chloro-6-methyl-5,5-dioxo-6,11-dihydrodibenzo(c,f)(1,2)thiazepin-11-yl)amino)heptanoate and intermediates. The invention also encompasses isolation of an essentially non-hygroscopic compound which is substantially pure.