Reference

Influence of the novel antidepressant tianeptine on neurochemical, neuroendocrinological, and behavioral effects of stress in rats

Influence of the novel antidepressant tianeptine on neurochemical, neuroendocrinological, and behavioral effects of stress in rats. Broqua, Pierre; Baudrie, Veronique; Laude, Dominique; Chaouloff, Francis (Dep. Pharmacol., CHU Necker-EM, Paris 75015, Fr.). Biol. Psychiatry, 31(4), 391-400 (English) 1992. CODEN: BIPCBF.Some commonly used reagents like 54-16-0 and 66981-73-5 are used in this experiment. ISSN: 0006-3223. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Tianeptine is a novel tricyclic agent that activates the neuronal uptake of serotonin (5-hydroxytryptamine, 5-HT). Taking into account the antidepressant effect of tianeptine in animals and humans, the influence of a pretreatment with tianeptine (10 mg/kg IP 1 h beforehand) on some consequences of a single 2-h restraint stress session was measured in male rats. Thus, 5-HT metab. in various brain regions and plasma glucose (an index of sympathoadrenal activity) and corticosterone levels at the end of stress was analyzed, and open field scores 18-19 h after immobilization in saline- or tianeptine-pretreated rats was obsd. Tianeptine was found to leave unaltered stress-induced increases in cortical, hippocampal, hypothalamic, midbrain, and striatal serotonergic metab. Similarly, stress-elicited elevations in plasma glucose and corticosterone levels were not affected by tianeptine pretreatment. On the other hand, tianeptine pretreatment reversed stress-induced deficit in exploratory activity. To test whether the latter pos. effect of tianeptine was assocd. with changes in plasma glucose and corticosterone levels during the early phase of stress, plasma glucose and corticosterone levels (at 0, 5, 15, 30, and 60 min) were measured in resting and stressed (catheterized) rats. The results indicated that tianeptine pretreatment did not alter plasma glucose and corticosterone early responses to stress. Although this study confirmed the antidepressant effect of tianeptine, the neurochem. and neuroendocrinol. mechanisms underlying this pos. effect remain to be detd. .

Tianeptine increases the extracellular concentrations of dopamine in the nucleus accumbens by a serotonin-independent mechanism

Tianeptine increases the extracellular concentrations of dopamine in the nucleus accumbens by a serotonin-independent mechanism. Invernizzi, R.; Pozzi, L.Several substances are used for example 306-08-1 and 66981-73-5 which are their cas registry numbers.; Garattini, S.; Samanin, R. (Ist. Ric. Farmacol. "Mario Negri", Milan 20157, Italy). Neuropharmacology, 31(3), 221-7 (English) 1992. CODEN: NEPHBW. ISSN: 0028-3908. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The effects of various doses of tianeptine on the extracellular concns. of dopamine was studied in the striatum and nucleus accumbens of the rat. At 5 (but not 2.5) mg/kg i.p., tianeptine increased the extracellular dopamine only in the nucleus accumbens. At 10 mg/kg, the effect was also seen in the striatum but it was less marked and shorter-lasting. At 10 mg/kg (e.p.), tianeptine significantly raised the extracellular concns of dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) in both regions. The effect of 10 mg/kg tianeptine on dopamine and its metabolites was not significantly changed in animals which had received this dose twice daily for 15 days. Intracerebroventricular administration of150 mg/20 ML 5,7-dihydroxytryptamine, which markedly depleted serotonin in the brain, did not modify the effect of 10 mg/kg tianeptine on the extracellular concns. of dopamine and HVA in the nucleus accumbens but reduced the effect on DOPAC. Various doses of tianeptine (1, 3, and 10 mg/kg i.p.) did not change the synthesis of serotonin and dopamine in the striatum and nucleus accumbens. The results show that tianeptine increased the extracellular concns. of dopamine more in the nucleus accumbens than in striatum. The effect on the output of DA in the nucleus accumbens could be involved in the antidepressant activity of tianeptine. .