670242-77-0

Basic information

• Product Name: ethyl 3-(4,8-dimethyl-2-oxo-7-phenacyloxychromen-3-yl)propanoate
• Synonyms: ethyl 3-(4,8-dimethyl-2-oxo-7-phenacyloxychromen-3-yl)propanoate
• CAS NO: 670242-77-0
• Molecular Formula: C₂₄H₂₄O₆
• Molecular Weight: 408.44376
• Mol File: 670242-77-0.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: ethyl 3-(4,8-dimethyl-2-oxo-7-phenacyloxychromen-3-yl)propanoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 3-(4,8-dimethyl-2-oxo-7-phenacyloxychromen-3-yl)propanoate(670242-77-0)
• EPA Substance Registry System: ethyl 3-(4,8-dimethyl-2-oxo-7-phenacyloxychromen-3-yl)propanoate(670242-77-0)

Safety Data

• Hazardous Substances Data: 670242-77-0(Hazardous Substances Data)

Upstream product

• 70-11-1 α-bromoacetophenone 
• 251361-29-2 ethyl 3-(7'-hydroxy-4',8'-dimethyl-2'-oxochromen-3'-yl)propanoate 
• 608-25-3 2-methylbenzene-1,3-diol 
• 1501-06-0 diethyl 2-acetylglutarate 

Relevant articles and documents

PSORALEN DERIVATIVES AS NON-PEPTIDIC INHIBITORS OF CHYMOTRYPSIN-LIKE ACTIVITY OF THE IMMUNOPROTEASOME

This invention relates to new inhibitors of chymothrypsin-like activity of the immunoproteasome (inhibitors of β5? or LMP7 subunit) with the general formula (I), where substituents are described in patent description. Compounds can be in the form of pure enantiomers or as racemic mixtures, or in the form of pharmaceutically acceptable salts. The present invention relates to the use of these inhibitors for the treatment of diseases where immunoproteasome activity is increased.

Synthesis of modified psoralen analogues

Substituted 3-(5-methyl-7-oxofuro[3,2-g]chromen-6-yl)propanoic acids analogous to psoralen were synthesized by linear annulation of a furan moiety to the coumarin system.