67083-22-1

Basic information

• Product Name: N-(2,6-dimethyl-4-nitrophenyl)-4-methylbenzenesulfonamide
• CAS NO: 67083-22-1
• Molecular Formula: C₁₅H₁₆N₂O₄S
• Molecular Weight: 320.3635
• Mol File: 67083-22-1.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 485.9°C at 760 mmHg
• Flash Point: 247.6°C
• Density: 1.339g/cm³
• Vapor Pressure: 1.36E-09mmHg at 25°C
• Refractive Index: 1.618
• CAS DataBase Reference: N-(2,6-dimethyl-4-nitrophenyl)-4-methylbenzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2,6-dimethyl-4-nitrophenyl)-4-methylbenzenesulfonamide(67083-22-1)
• EPA Substance Registry System: N-(2,6-dimethyl-4-nitrophenyl)-4-methylbenzenesulfonamide(67083-22-1)

Safety Data

• Hazardous Substances Data: 67083-22-1(Hazardous Substances Data)

Upstream product

• 4703-15-5 N-(2,6-dimethylphenyl)-4-methylbenzenesulfonamide 
• 98-59-9 p-toluenesulfonyl chloride 
• 87-62-7 2,6-dimethylaniline 

Downstream Products

• 16947-63-0 2,6-dimethyl-4-nitroaniline 
• 294853-97-7 N-(4-amino-2,6-dimethylphenyl)-4-methylbenzenesulfonamide 
• 67083-23-2 2-chloro-N-(2,6-dimethyl-4-nitrophenyl)acetamide 
• 67083-24-3 2-(diethylamino)-N-(2,6-dimethyl-4-nitrophenyl)acetamide 
• 85802-74-0 N,2,6-trimethyl-4-nitroaniline 

Relevant articles and documents

Self-Immolative System for Disclosure of Reactive Electrophilic Alkylating Agents: Understanding the Role of the Reporter Group

The development of stable, efficient chemoselective self-immolative systems, for use in applications such as sensors, requires the optimization of the reactivity and degradation characteristics of the self-immolative unit. In this paper, we describe the effect that the structure of the reporter group has upon the self-immolative efficacy of a prototype system designed for the disclosure of electrophilic alkylating agents. The amine of the reporter group (a nitroaniline unit) was a constituent part of a carbamate that functioned as the self-immolative unit. The number and position of substituents on the nitroaniline unit were found to play a key role in the rate of self-immolative degradation and release of the reporter group. The position of the nitro substituent (meta- vs para-) and the methyl groups in the ortho-position relative to the carbamate exhibited an influence on the rate of elimination and stability of the self-immolative system. The ortho-methyl substituents imparted a twist on the N-C (aromatic) bond leading to increased resonance of the amine nitrogen's lone pair into the carbonyl moiety and a decrease of the leaving character of the carbamate group; concomitantly, this may also make it a less electron-withdrawing group and lead to less acidification of the eliminated β-hydrogen.

PLASMA KALLIKREIN INHIBITORS AND USES THEREOF

The present invention provides compounds and compositions thereof which are useful as inhibitors of plasma kallikrein and which exhibit desirable characteristics for the same.

NOVEL KCNQ POTASSIUM CHANNEL AGONIST, AND PREPARATION METHOD THEREFOR AND USE THEREOF

The present invention provides a compound represented by general formula I or a pharmaceutical acceptable salt thereof, the preparation method therefor and the use thereof in preparing a medicine for treating a neurological disease, such as epilepsy, conv