67191-35-9

Basic information

• Product Name: Benzene, 1-ethenyl-2-(1-Methylethoxy)-
• Synonyms: Benzene, 1-ethenyl-2-(1-Methylethoxy)-;1-ETHENYL-2-(1-METHYLETHOXY)-BENZENE
• CAS NO: 67191-35-9
• Molecular Formula: C₁₁H₁₄O
• Molecular Weight: 162.22826
• EINECS: -0
• Mol File: 67191-35-9.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 231.2±9.0 °C(Predicted)
• Appearance: /
• Density: 0.938±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Benzene, 1-ethenyl-2-(1-Methylethoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-ethenyl-2-(1-Methylethoxy)-(67191-35-9)
• EPA Substance Registry System: Benzene, 1-ethenyl-2-(1-Methylethoxy)-(67191-35-9)

Safety Data

• Hazardous Substances Data: 67191-35-9(Hazardous Substances Data)

Upstream product

• 90-02-8 salicylaldehyde 
• 857335-90-1 1-iodo-2-isopropoxybenzene 
• 533-58-4 2-Iodophenol 
• 66021-95-2 1-ethynyl-2-isopropoxybenzene 
• 592-41-6 1-hexene 
• 301224-40-8 Hoveyda-Grubbs catalyst second generation 
• 1885-81-0 p-chlorophenyl isocyanide 
• 1779-49-3 Methyltriphenylphosphonium bromide 
• 22921-58-0 2-isopropoxybenzaldehyde 

Downstream Products

• 301224-40-8 (1,3-dimesityl-4,5-dihydroimidazol-2-ylidene)Cl₂Ru=CH-o-OiPrC₆H₄ 
• 301224-40-8 Hoveyda-Grubbs catalyst second generation 

Relevant articles and documents

Large-Scale Synthesis of a Niche Olefin Metathesis Catalyst Bearing an Unsymmetrical N-Heterocyclic Carbene (NHC) Ligand and its Application in a Green Pharmaceutical Context

A large-scale synthesis of known Ru olefin metathesis catalyst VII featuring an unsymmetrical N-heterocyclic carbene (NHC) ligand with one 2,5-diisopropylphenyl (DIPP) and one thiophenylmethylene N-substituent is reported. The optimised procedure does not require column chromatography in any step and allows for preparation of up to 0.5 kg batches of the catalyst from simple precursors. The application profile of the obtained catalyst was studied in environmentally friendly dimethyl carbonate (DMC). Although VII exhibited low efficiency in cross-metathesis (CM) with electron-deficient partners, good to excellent results were noted for substrates featuring easy to isomerise C?C double bonds. This includes polyfunctional substrates of medicinal chemistry interest, such as analogues of psychoactive 5F-PB-22 and NM-2201 and two PDE5 inhibitors—Sildenafil and Vardenafil. Finally, a larger scale ring-closing metathesis (RCM) of a Vardenafil derivative was conducted in DMC, allowing for straightforward isolation of the expected product (23 g) in high yield and with low Ru contamination level (7.7 ppm).

Palladium-Catalyzed Atom-Transfer Radical Cyclization at Remote Unactivated C(sp3)?H Sites: Hydrogen-Atom Transfer of Hybrid Vinyl Palladium Radical Intermediates

A novel mild, visible-light-induced palladium-catalyzed hydrogen atom translocation/atom-transfer radical cyclization (HAT/ATRC) cascade has been developed. This protocol involves a 1,5-HAT process of previously unknown hybrid vinyl palladium radical intermediates, thus leading to iodomethyl carbo- and heterocyclic structures.

COMPOUNDS AND THE USE THEREOF IN METATHESIS REACTIONS

The disclosure provides Group 6 complexes, which, in some embodiments, are useful for catalyzing olefin metathesis reactions. In some embodiments, the compounds are compounds of the following formula (I) wherein: M is a Group 6 metal atom; X is an oxygen