67274-54-8

Basic information

• Product Name: Benzenamine, 4-bromo-N-ethyl-N-methyl-
• CAS NO: 67274-54-8
• Molecular Formula: C9H12BrN
• Molecular Weight: 214.105
• Mol File: 67274-54-8.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: Benzenamine, 4-bromo-N-ethyl-N-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenamine, 4-bromo-N-ethyl-N-methyl-(67274-54-8)
• EPA Substance Registry System: Benzenamine, 4-bromo-N-ethyl-N-methyl-(67274-54-8)

Safety Data

• Hazardous Substances Data: 67274-54-8(Hazardous Substances Data)

Upstream product

• 50438-47-6 N-(4-bromo-phenyl)-N-methylacetamide 
• 75-03-6 ethyl iodide 
• 106-40-1 4-bromo-aniline 
• 74-88-4 methyl iodide 
• 624-78-2 N-Ethylmethylamine 
• 589-87-7 1,4-bromoiodobenzene 
• 100-61-8 N-methylaniline 
• 7664-93-9 sulfuric acid 
• 861569-95-1 N-ethyl-N-(4-bromo-phenyl)-glycine nitrile 
• 88799-13-7 (4-Bromo-phenyl)-ethyl-methyl-amine; compound with bromine 
• 613-97-8 N-methyl-N-ethylaniline 

Downstream Products

• 88799-13-7 (4-Bromo-phenyl)-ethyl-methyl-amine; compound with bromine 

Relevant articles and documents

Sodium Triethylborohydride-Catalyzed Controlled Reduction of Unactivated Amides to Secondary or Tertiary Amines

The first transition-metal-free catalytic protocol for controlled reduction of amide functions using cheap and bench-stable hydrosilanes as reducing agents has been established. By altering the hydrosilane and solvent, the new method enables the selective cleavage of unactivated C-O bonds in amides and allows the C-N bonds to selectively break via the deacylated cleavage. Overall, this novel process may offer a versatile alternative to current methodologies employing stoichiometric metal systems for the controlled reduction of carboxamides.

Ru-Catalyzed Deoxygenative Transfer Hydrogenation of Amides to Amines with Formic Acid/Triethylamine

A ruthenium(II)-catalyzed deoxygenative transfer hydrogenation of amides to amines using HCO2H/NEt3 as the reducing agent is reported for the first time. The catalyst system consisting of [Ru(2-methylallyl)2(COD)], 1,1,1-tris(diphenylphosphinomethyl) ethane (triphos) and Bis(trifluoromethane sulfonimide) (HNTf2) performed well for deoxygenative reduction of various secondary and tertiary amides into the corresponding amines in high yields with excellent selectivities, and exhibits high tolerance toward functional groups including those that are reduction-sensitive. The choice of hydrogen source and acid co-catalyst is critical for catalysis. Mechanistic studies suggest that the reductive amination of the in situ generated alcohol and amine via borrowing hydrogen is the dominant pathway. (Figure presented.).

Method for selective reducing reaction of tertiary aryl amide and borane

The present invention relates to a method for a selective reducing reaction of a tertiary aryl amide and borane. A tertiary amine product is prepared by the reducing reaction of a tertiary aryl amidederivative and a cheap and easily available organoboron reagent under mild conditions under the convenient catalysis of a non-transition metal compound sodium triethylborohydride used as a catalyst for the first time. Compared with traditional methods, the method of the method generally has the advantages of wide universality of a substrate, low cost and easy availability of the catalyst, and simplicity in reaction operation. The selective reducing reaction of the tertiary aryl amide compound and the organoboron reagent under the catalysis of the transition metal catalyst is realized for the first time, and a brand new "green" reaction strategy is provided for the laboratory preparation or industrial production of tertiary arylamine products.