6738-23-4Relevant articles and documents
Preparation method of nitrogen-alkyl (deuterated alkyl) aromatic heterocycle and alkyl (deuterated alkyl) aryl ether compound
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Paragraph 0093-0098, (2021/04/03)
The invention provides a method for preparing nitrogen-alkyl(deuterated alkyl)aromatic heterocycle and alkyl(deuterated alkyl)aryl ether compounds. The method adopted in the invention specifically comprises the following steps: firstly, adding an alkoxy base (MOR') or a combination reagent Q (comprising a base M'X, an alcohol C and a molecular sieve E) into a solvent B to be stirred; then, addingan aromatic compound D of nitrogen sulfonyl or oxygen sulfonyl into a mixture; separating and purifying after reaction to obtain nitrogen-alkyl(deuterated alkyl)aromatic heterocycle or alkyl(deuterated alkyl)aryl ether. The method can realize one-step conversion from an electron withdrawing benzenesulfonyl protecting group on a nitrogen or oxygen atom to an electron donating alkyl protecting group, avoids using highly toxic alkyl halide, and has advantages of being efficient, economical, environmentally friendly, mild in condition, good in substrate universality and high in yield; the prepareddeuterated compounds can be widely applied to the fields of pharmaceutical chemistry and organic chemistry synthesis.
[OONN] tetradentate fourth subgroup metal complexes as well as preparation method and application thereof
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Paragraph 0032-0035, (2021/05/12)
The invention relates to the technical field of olefin polymerization catalysts, and particularly discloses [OONN] tetradentate fourth subgroup metal complexes, a preparation method and application. The [OONN] tetradentate fourth subgroup metal complexes have a structure which is shown in the specification. The [OONN] tetradentate fourth subgroup metal complexes provided by the invention can catalyze ethylene polymerization and ethylene and alpha-olefin copolymerization, and in the polymerization process, the heat resistance is good, and the polymerization time is long. The complexes are simple in synthesis method, easy to prepare and high in yield, the structure is convenient to modify, the complexes can be used for catalyzing ethylene polymerization and ethylene and alpha-olefin copolymerization after being activated by a proper cocatalyst, the problems that an existing olefin polymerization catalyst is relatively tedious in preparation process, high in cost and low in catalytic activity are solved, and the complexes have good industrial application value and wide application field.
Detosylative (Deutero)alkylation of Indoles and Phenols with (Deutero)alkoxides
Zhu, Ming-Hui,Yu, Cheng-Long,Feng, Ya-Lan,Usman, Muhammad,Zhong, Dayou,Wang, Xin,Nesnas, Nasri,Liu, Wen-Bo
supporting information, p. 7073 - 7077 (2019/09/30)
An efficient strategy for N/O-(deutero)alkylation of indoles and phenols with alkoxides/alcohols as the alkylation reagents is described. The consecutive detosylation/alkylation transformations feature mild reaction conditions, high ipso-selectivity, and good functional group tolerance (>50 examples). A one-pot selective N-alkylation of unprotected indoles with alcohols and TsCl is also realized. The application of this method is demonstrated by the introduction of isotope-labeled (CD3 and 13CH3) groups using the readily accessible labeled alcohols and the synthesis of pharmaceuticals.
