677728-84-6

Basic information

• Product Name: 3,5-difluoro-N-hydroxybenzenecarboximidoyl chloride
• Synonyms: 3,5-difluoro-N-hydroxybenzenecarboximidoyl chloride
• CAS NO: 677728-84-6
• Molecular Weight: 191.565
• Mol File: 677728-84-6.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 3,5-difluoro-N-hydroxybenzenecarboximidoyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-difluoro-N-hydroxybenzenecarboximidoyl chloride(677728-84-6)
• EPA Substance Registry System: 3,5-difluoro-N-hydroxybenzenecarboximidoyl chloride(677728-84-6)

Safety Data

• Hazardous Substances Data: 677728-84-6(Hazardous Substances Data)

Upstream product

• 677728-83-5 3,5-difluorobenzaldehyde oxime 
• 32085-88-4 3,5-difluorobenzaldehyde 

Downstream Products

• 1442459-63-3 3-(3,5-difluorophenyl)-5-phenylisoxazole 
• 1442459-65-5 3-(3,5-difluorophenyl)-5-octylisoxazole 

Relevant articles and documents

Design, synthesis, and in vitro evaluation of novel antifungal triazoles

Twenty-nine novel triazole analogues of ravuconazole and isavuconazole were designed and synthesized. Most of the compounds exhibited potent in vitro antifungal activities against 8 fungal isolates. Especially, compounds a10, a13, and a14 exhibited superior or comparable antifungal activity to ravuconazole against all the tested fungi. Structure-activity relationship study indicated that replacing 4-cyanophenylthioazole moiety of ravuconazole with fluorophenylisoxazole resulted in novel antifungal triazoles with more effectiveness and a broader-spectrum.

Design, synthesis, and in vitro evaluation of novel triazole analogues featuring isoxazole moieties as antifungal agents

In order to develop novel antifungal agents, based on our previous work, a series of (2R,3R)-3-((3-substitutied-isoxazol-5-yl)methoxy)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl) butan-2-ol (a1-a26) were designed and synthesized. All of the compounds exhibited good in vitro antifungal activities against eight human pathogenic fungi. Among them, compound a6 showed excellent inhibitory activity against Candida albicans and Candida parasilosis with MIC80 values of 0.0313 μg/mL. In addition, compounds a6, a9, a12, a13 and a14 exhibited moderate inhibitory activities against fluconazole-resistant isolates with MIC80 values ranging from 8 μg/mL to 16 μg/mL. Furthermore, compounds a6, a12 and a23 exhibited low inhibition profiles for CYP3A4. Clear SARs were analyzed, and the molecular docking experiment was carried out to further investigate the relationship between a6 and the target enzyme CYP51.

Triazole alcohol derivative and preparation method and application thereof

The invention relates to a triazole alcohol derivative and a preparation method and application thereof. The chemical structure of the triazole alcohol derivative is as shown in the formula I. The invention also provides salt of the compound, a pharmaceutical composition, a preparation method and application. The compound of the invention has strong antifungal activity, has advantages of low toxicity and wide antimicrobial spectrum, and can be used for preparation of antifungal drugs.