1442459-63-3

Basic information

• Product Name: 3-(3,5-difluorophenyl)-5-phenylisoxazole
• CAS NO: 1442459-63-3
• Molecular Weight: 257.239
• Mol File: 1442459-63-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-(3,5-difluorophenyl)-5-phenylisoxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3,5-difluorophenyl)-5-phenylisoxazole(1442459-63-3)
• EPA Substance Registry System: 3-(3,5-difluorophenyl)-5-phenylisoxazole(1442459-63-3)

Safety Data

• Hazardous Substances Data: 1442459-63-3(Hazardous Substances Data)

Upstream product

• 677728-84-6 3,5-difluoro-N-hydroxybenzenecarboximidoyl chloride 
• 536-74-3 phenylacetylene 
• 32085-88-4 3,5-difluorobenzaldehyde 

Relevant articles and documents

Montmorillonite clay Cu(II) catalyzed domino one-pot multicomponent synthesis of 3,5-disubstituted isoxazoles

A simple and efficient one-pot multicomponent approach for the synthesis of 3,5-disubstituted isoxazoles directly from corresponding aldehydes and terminal alkynes using recyclable montmorillonite clay supported Cu(II)/NaN3 catalytic system under aqueous conditions have been developed. The 'domino' one-pot MCR approach involves hydroxyamination of aldehydes followed by chlorination and then generation of reactive 'nitrile oxide' which undergoes 1,3-dipolar cycloaddition with alkynes to produce 3,5-disubstituted isoxazoles. The method is operationally simple, regioselective, economical, and possesses excellent functional group compatibility to synthesize structurally diverse isoxazoles in good yields.