67970-80-3

Basic information

• Product Name: 2(1H)-Pyridinone, 1-methyl-4-phenyl-
• Synonyms: 2(1H)-Pyridinone, 1-methyl-4-phenyl-
• CAS NO: 67970-80-3
• Molecular Formula: C₁₂H₁₁NO
• Molecular Weight: 185.22
• Mol File: 67970-80-3.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 363.9°C at 760 mmHg
• Flash Point: 175°C
• Appearance: /
• Density: 1.137g/cm³
• Vapor Pressure: 1.75E-05mmHg at 25°C
• Refractive Index: 1.592
• CAS DataBase Reference: 2(1H)-Pyridinone, 1-methyl-4-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2(1H)-Pyridinone, 1-methyl-4-phenyl-(67970-80-3)
• EPA Substance Registry System: 2(1H)-Pyridinone, 1-methyl-4-phenyl-(67970-80-3)

Safety Data

• Hazardous Substances Data: 67970-80-3(Hazardous Substances Data)

Usage

Type

Chemical compound; derivative of pyridinone

Known for

Neurotoxic effects; inducing Parkinson's disease in animal models

Linked to

Development of Parkinson's disease in humans; destruction of dopamine-producing neurons in the brain

Researched for

Understanding mechanisms of Parkinson's disease; developing potential treatments; studying other neurodegenerative disorders, such as Alzheimer's disease.

InChI:InChI=1/C12H11NO/c1-13-8-7-11(9-12(13)14)10-5-3-2-4-6-10/h2-9H,1H3

Upstream product

• 939-23-1 p-phenylpyridine 
• 77-78-1 dimethyl sulfate 
• 36953-37-4 4-bromo-2(1H)-pyridinone 
• 73583-37-6 2-chloro-4-bromopyridine 
• 214342-63-9 4-bromo-1-methyl-1,2-dihydropyridin-2-one 
• 98-80-6 phenylboronic acid 
• 19006-81-6 4-phenylpyridin-2-one 
• 74-88-4 methyl iodide 

Downstream Products

• 128127-14-0 N-phenyl-2-methyl-8-phenyl-3-oxo-2-azabicyclo<2.2.2>oct-7-ene-5,6-endo-dicarboximide 
• 939-23-1 p-phenylpyridine 
• 28289-54-5 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine 
• 176514-83-3 1-methyl-4-phenyl-2-pyridone-6-d1 
• 173278-81-4 1-methyl-4-phenyl-3,6-dihydro-2-pyridone 
• 122842-52-8 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-6,6-d2 
• 176514-84-4 1-methyl-4-phenyl-3,6-dihydro-2-pyridone-6,6-d2 
• 94515-22-7 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridin-2-one 
• 118459-65-7 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-2,2,6,6-d4 
• 72248-89-6 dimethyl 2-methyl-3-oxo-5-phenyl-2-azabicyclo<2.2.2>octa-5,7-diene-7,8-dicarboxylate 
• 127956-32-5 1,2-dihydro-2-benzoyl-cyanomethylidene-1-methyl-pyridine 
• 127956-33-6 1,2-dihydro-2-(4-methoxybenzoyl-cyanomethylidene)-1-methyl-pyridine 
• 127956-34-7 1,2-dihydro-2-(4-nitrobenzoyl-cyanomethylidene)-1-methyl-pyridine 

Relevant articles and documents

Asymmetric Homogeneous Hydrogenation of 2-Pyridones

An asymmetric homogeneous hydrogenation of 2(1H)-pyridones has been developed, using a ruthenium complex bearing two chiral N-heterocyclic carbene (NHC) ligands. To the best of our knowledge, the presented reaction is the first example of a homogeneous asymmetric conversion of 2-pyridones into the corresponding enantioenriched 2-piperidones.

Reactions of 1-unsubstituted tautomeric 2-pyridones with benzyne

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Studies on the syntheses of 2(1H)-pyridone derivatives. I. Synthesis and pharmacological property of 6-substituted 2(1H)-pyridones

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