68282-47-3

Basic information

• Product Name: 2-PHENYL-1H-IMIDAZOLE-4-CARBOXALDEHYDE
• Synonyms: 2-phenyl-1H-imidazole-4-carbaldehyde;2-PHENYL-1H-IMIDAZOLE-4-CARBOXALDEHYDE;2-PHENYL-4-FORMYLIMIDAZOLE;2-PHENYLIMIDAZOLE-4-CARBOXALDEHYDE;4(5)-FORMYL-2-PHENYLIMIDAZOLE;2-PHENYL-1H-IMIDAZOLE-5-CARBALDEHYDE;4-Formyl-2-phenyl-1H-imidazole, (4-Formyl-1H-imidazol-2-yl)benzene;2-Phenyl-1H-imidazole-5-carboxaldehyde
• CAS NO: 68282-47-3
• Molecular Formula: C₁₀H₈N₂O
• Molecular Weight: 172.18
• Product Categories: pharmacetical
• Mol File: 68282-47-3.mol
• Article Data: 12

Chemical Properties

• Melting Point: 167-169°C
• Boiling Point: 418.9 °C at 760 mmHg
• Flash Point: 208.7 °C
• Appearance: /
• Density: 1.248
• Vapor Pressure: 3.17E-07mmHg at 25°C
• Refractive Index: 1.646
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 11.23±0.10(Predicted)
• CAS DataBase Reference: 2-PHENYL-1H-IMIDAZOLE-4-CARBOXALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-PHENYL-1H-IMIDAZOLE-4-CARBOXALDEHYDE(68282-47-3)
• EPA Substance Registry System: 2-PHENYL-1H-IMIDAZOLE-4-CARBOXALDEHYDE(68282-47-3)

Safety Data

• Hazard Codes: Xn:Harmful
• Statements: 21/22-36
• Safety Statements: 22-36/37/39-26
• HazardClass: IRRITANT
• Hazardous Substances Data: 68282-47-3(Hazardous Substances Data)

Usage

General Description

2-Phenyl-1H-imidazole-4-carboxaldehyde is a chemical compound with the molecular formula C10H8N2O. It is a yellowish solid with a molecular weight of 172.18 g/mol. 2-Phenyl-1H-imidazole-4-carboxaldehyde is used in organic synthesis and is a precursor for the preparation of a variety of pharmaceuticals and fine chemicals. It can also be used as a reagent in the synthesis of imidazole derivatives and other organic compounds. 2-Phenyl-1H-imidazole-4-carboxaldehyde has applications in the pharmaceutical industry and is an important building block for the production of many drugs and active pharmaceutical ingredients.

InChI:InChI=1/C10H8N2O/c13-7-9-6-11-10(12-9)8-4-2-1-3-5-8/h1-7H,(H,11,12)

Upstream product

• 43002-54-6 5-hydroxymethyl-2-phenyl-1H-imidazole 
• 100-52-7 benzaldehyde 
• 43002-54-6 (2-phenyl-1H-imidazol-4-yl)-methanol 
• 1449431-44-0 N,N-dimethyl-2-phenyl-1H-imidazole-1-sulfonamide 
• 68-12-2 N,N-dimethyl-formamide 
• 670-96-2 2-Phenylimidazole 

Downstream Products

• 94938-03-1 1-methyl-2-phenyl-1H-imidazole-5-carboxaldehyde 
• 94938-02-0 1-methyl-2-phenyl-1H-imidazole-4-carboxaldehyde 
• 623906-14-9 (5R)-6-{acetoxy-[1-(4-nitrobenzyloxycarbonyl)-2-phenyl-1H-imidazol-4-yl]methyl}-6-bromo-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitrobenzyl ester 

Relevant articles and documents

13C CPMAS NMR as a tool for full structural description of 2-phenyl substituted imidazoles that overcomes the effects of fast tautomerization

Tautomerization of 2-phenylimidazolecarbaldehydes has not been studied in detail so far, although this process is a well-known phenomenon for imidazole derivatives. That is why we focus our study on a series of 2-phenylimidazolecarbaldehydes and their par

Imidazole-based pinanamine derivatives: Discovery of dual inhibitors of the wild-type and drug-resistant mutant of the influenza A virus

We previously reported potent hit compound 4 inhibiting the wild-type influenza A virus A/HK/68 (H3N2) and A/M2-S31N mutant viruses A/WS/33 (H1N1), with its latter activity quite weak. To further increase its potency, a structure-activity relationship study of a series of imidazole-linked pinanamine derivatives was conducted by modifying the imidazole ring of this compound. Several compounds of this series inhibited the amantadine-sensitive virus at low micromolar concentrations. Among them, 33 was the most potent compound, which was identified as being active on an amantadine-sensitive virus through blocking of the viral M2 ion channel. Furthermore, 33 markedly inhibited the amantadine-resistant virus (IC50 = 3.4 μM) and its activity increased by almost 24-fold compared to initial compound, with its action mechanism being not M2 channel mediated.

PIPERIDINE-CONTAINING COMPOUNDS AND USE THEREOF

A method for preventing and/or treating a metabolic disease, cerebrovascular disease, etc. which comprises administering to a mammal an effective amount of the compound of the formula (I) wherein all symbols have the same meanings as defined in the specification; a salt thereof, an N-oxide thereof, a solvate thereof, or a prodrug thereof. And a novel compound of the formula (I-1): wherein all symbols have the same meanings as defined in the specification; a salt thereof, an N-oxide thereof, a solvate thereof, or a prodrug thereof has an anti-diabetic effect and a neuroprotective effect. Accordingly, the compound of the formula (I) and the compound of the formula (I-1) are useful in a method for preventing and/or treating for a metabolic disease such as diabetes, cerebrovascular disease such as stroke, etc.