68307-79-9

Basic information

• Product Name: 2-Propenoic acid, 3-(3,4-dihydroxyphenyl)-2-hydroxy-
• CAS NO: 68307-79-9
• Molecular Formula: C9H8O5
• Molecular Weight: 196.16
• Mol File: 68307-79-9.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-Propenoic acid, 3-(3,4-dihydroxyphenyl)-2-hydroxy-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenoic acid, 3-(3,4-dihydroxyphenyl)-2-hydroxy-(68307-79-9)
• EPA Substance Registry System: 2-Propenoic acid, 3-(3,4-dihydroxyphenyl)-2-hydroxy-(68307-79-9)

Safety Data

• Hazardous Substances Data: 68307-79-9(Hazardous Substances Data)

Upstream product

• 65329-03-5 2-(acetylamino)-3-[3,4-bis(acetyloxy)phenyl]-(2Z)-2-propenoic acid 
• 139-85-5 3,4-dihydroxybenzaldehyde 
• 87950-39-8 (Z)-4-((2-methyl-5-oxooxazol-4(5H)-ylidene)methyl)-1,2-phenylene diacetate 
• 64521-33-1 2-acetylamino-3-(3,4-dihydroxyphenyl)-propenoic acid 
• 63-84-3 dopa 
• 65329-03-5 α-acetylamino-β-(3,4-diacetoxyphenyl)acrylic acid 

Downstream Products

• 1162198-69-7 (Z)-2-acetoxy-3-(3,4-diacetoxyphenyl)acrylic acid 
• 69914-80-3 3-(3,4-diacetoxyphenyl)propanoic acid 
• 100976-95-2 2-acetoxy-3-(3,4-diacetoxyphenyl)propanoic acid 
• 1400221-79-5 N-((R)-3-benzylthio-1-methoxy-1-oxo-2-propanyl)-2-acetoxy-3-(3,4-diacetoxyphenyl)propanamide 
• 1400221-75-1 N-((R)-3-benzylthio-1-methoxy-1-oxo-2-propanyl)-2-acetoxy-3-(3,4-diacetoxyphenyl)propenamide 
• 1400221-84-2 N-((R)-3-benzylthio-1-methoxy-1-oxo-2-propanyl)-3-(3,4-diacetoxyphenyl)propanamide 
• 1314941-72-4 S-((R)-3-methoxy-3-oxo-2-(tert-butoxycarbonylamino)propyl) ((2-acetoxy)-3-(3,4-methylenedioxyphenyl))propenethioate 
• 1314941-70-2 S-((R)-3-methoxy-3-oxo-2-(tert-butoxycarbonylamino)propyl) 3-(3,4-diacetoxyphenyl)propanethioate 
• 1314941-58-6 S-((R)-3-methoxy-3-oxo-2-aminopropyl) 2-acetoxy-3-(3,4-diacetoxyphenyl)propanethioate 
• 23028-17-3 danshensu 
• 868785-50-6 IDHP 
• 1280727-98-1 isopropyl (S)-3-(3,4-dihydroxyphenyl)-2-hydroxypropanoate 
• 950665-05-1 isopropyl (R)-3-(3,4-dihydroxyphenyl)-2-hydroxypropanoate 
• 1314941-60-0 S-((R)-3-methoxy-3-oxo-2-aminopropyl) 3-(3,4-diacetoxyphenyl)propanethioate 

Relevant articles and documents

Tanshinol and H2 S/NO Donor binding, preparation method thereof and application in pharmacy (by machine translation)

The invention belongs to the field of chemical pharmacy, and relates to active ingredient tanshinol and H in Chinese herbal medicine Salvia miltiorrhiza. 2 S/NO Donors and its preparation method and use in pharmacy, especially in the preparation of medicines for preventing and treating cardiovascular and cerebrovascular diseases and inflammation related diseases. To the invention, through in-vitro oxidative stress injury and inflammation model experiments, the results show that H is obviously inhibited. 2 O2 In vivo activity experiment results show that the conjugate is capable of remarkably inhibiting the release of inflammatory cytokines induced by LPS (LPS), reducing inflammation-induced mouse peritoneal macrophages, obviously inhibiting the release of inflammatory cytokines induced by LPS, and showing the result that the compound can be used for preparing drugs for preventing and treating cardiovascular and cerebrovascular diseases and inflammatory diseases. (by machine translation)

The synthesis and biological evaluation of novel Danshensu-cysteine analog conjugates as cardiovascular-protective agents

A series of novel amide and thioester conjugates between Danshensu and cysteine derivatives have been designed and synthesized based on the strategy of "medicinal chemical hybridization". Pharmacological evaluation indicated that the amide conjugates 3a/4a/17a and thioester conjugates 6a-d exhibited obvious protective effects on H2O2-induced human umbilical vein endothelial cells (HUVECs). Pretreated with these conjugates could increase glutathione (GSH) activity and decrease malondialdehyde (MDA) level. Further study on mechanism of compound 4a revealed that it was related to its mitochondrial-protective effect and regulation of apoptosis-related proteins expression (Bax, p53, PARP, caspase-3, caspase-9 and Bcl-2). These results indicate that these Danshensu-cysteine analog conjugates possess significant cardiovascular-protective effects and merit further investigation.

Conversion of Phenolic α-Amino Acids into α-Keto Acids

A one-pot conversion of tyrosine (1a) and 3,4-dihydroxyphenylalanine (DOPA) (1b) into 3-(4-hydroxyphenyl)pyruvic acid (2a) and 3-(3,4-dihydroxyphenyl)pyruvic acid (2b), respectively, via 2-trifluoromethyl-3-oxazolin-5-ones 5 is described.