6873-44-5

Basic information

• Product Name: 4-chloro-N-MethylbenzaMide
• Synonyms: 4-chloro-N-MethylbenzaMide
• CAS NO: 6873-44-5
• Molecular Formula: C₈H₈ClNO
• Molecular Weight: 169.60822
• EINECS: -0
• Mol File: 6873-44-5.mol
• Article Data: 57

Chemical Properties

• Boiling Point: 311.2°Cat760mmHg
• Flash Point: 142°C
• Appearance: /
• Density: 1.196g/cm³
• Vapor Pressure: 0.00057mmHg at 25°C
• Refractive Index: 1.544
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 4-chloro-N-MethylbenzaMide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chloro-N-MethylbenzaMide(6873-44-5)
• EPA Substance Registry System: 4-chloro-N-MethylbenzaMide(6873-44-5)

Safety Data

• Hazardous Substances Data: 6873-44-5(Hazardous Substances Data)

Usage

General Description

4-chloro-N-MethylbenzaMide is a chemical compound with the molecular formula C8H8ClNO. It is a white solid that is used as an intermediate in the synthesis of pharmaceuticals and other organic compounds. 4-chloro-N-MethylbenzaMide is also used in the production of various dyes and pigments. It is known for its ability to inhibit the activity of certain enzymes, making it useful in the development of drugs for treating various medical conditions. However, it is important to handle this compound with care as it can be toxic if ingested or inhaled. Overall, 4-chloro-N-MethylbenzaMide is an important chemical intermediate with various applications in the pharmaceutical and chemical industries.

InChI:InChI=1/C8H8ClNO/c1-10-8(11)6-2-4-7(9)5-3-6/h2-5H,1H3,(H,10,11)

Upstream product

• 122-01-0 4-chloro-benzoyl chloride 
• 74-89-5 methylamine 
• 60253-29-4 4-chloro-N-methyl-thiobenzamide 
• 14062-80-7 N,N-dimethyl-4-chlorobenzamide 
• 106-46-7 para-dichlorobenzene 
• 149-73-5 trimethyl orthoformate 
• 1126-46-1 Methyl 4-chlorobenzoate 
• 593-51-1 methylamine hydrochloride 
• 22979-74-4 N-allyl-4-chloro-N-methylbenzamide 
• 623-03-0 4-Cyanochlorobenzene 
• 67-56-1 methanol 
• 104-11-0 N-methyl-4-chlorobenzylamine 
• 106-39-8 bromochlorobenzene 
• 335344-28-0 N‐methoxymethyl‐N‐methylcarbamoyl(trimethyl)silane 

Downstream Products

• 82791-55-7 1-(4-Chloro-phenyl)-6,7-dimethoxy-2-methyl-2H-isoquinolin-3-one 
• 144175-29-1 4-Chloro-N-chloromethyl-N-methyl-benzamide 
• 134814-86-1 Benzoic acid [(4-chloro-benzoyl)-methyl-amino]-methyl ester 
• 39887-78-0 N-methyl 4-chlorobenzimidoyl chloride 
• 132606-42-9 4-Chloro-N-{(4-chloro-phenyl)-[(Z)-methylimino]-methyl}-N-methyl-benzamide 
• 1026370-84-2 3-(3-bromo-4,5-dimethoxy-phenyl)-5-chloro-3H-isobenzofuran-1-one 
• 144175-22-4 N-(diphenyloxophosphinyl)methyl-N-methyl-4-chlorobenzamide 
• 90110-19-3 4-Chlor-N-nitro-benzoesaeure-methylamid 
• 1315257-11-4 6-chloro-2-methyl-3,4-diphenylisoquinolin-1(2H)-one 
• 39887-18-8 4-chloro-N-(cyclohexylmethyl)benzamide 
• 7335-27-5 ethyl 4-chlorobenzoate 
• 1126-46-1 Methyl 4-chlorobenzoate 
• 225517-55-5 1-(3-bromo-4,5-dimethoxyphenyl)-7-chloro-2,3-bis(methoxycarbonyl)naphthalene 
• 225517-24-8 1-(3-bromo-4,5-dimethoxyphenyl)-7-chloro-2-(methoxycarbonyl)naphthalene-3-carboxylic acid 

Relevant articles and documents

Cobalt-catalyzed cyclization of 2-bromobenzamides with carbodiimides: A new route for the synthesis of 3-(imino)isoindolin-1-ones

A novel synthetic pathway to approach 3-(imino)isoindolin-1-ones by the Co-catalyzed cyclization reaction of 2-bromobenzamides with carbodiimides has been developed. This catalytic reaction can tolerate a variety of substituents and provide corresponding products in moderate yields for most cases. According to the literature, the reaction mechanism is proposed through the formation of a five-membered aza-cobalacycle complex, which carries out the following reaction subsequence, including nucleophilic addition and substitution, to furnish the desired structures.

Assemblies of 1,4-Bis(diarylamino)naphthalenes and Aromatic Amphiphiles: Highly Reducing Photoredox Catalysis in Water

Host-guest assemblies of a designed 1,4-bis(diarylamino)naphthalene and V-shaped aromatic amphiphiles consisting of two pentamethylbenzene moieties bridged by an m -phenylene unit bearing two hydrophilic side chains emerged as highly reducing photoredox catalysis systems in water. An efficient demethoxylative hydrogen transfer of Weinreb amides has been developed. The present supramolecular strategy permits facile tuning of visible-light photoredox catalysis in water.

Dealkoxylation ofN-alkoxyamides without an external reductant driven by Pd/Al cooperative catalysis

Lewis acid-assisted palladium-catalysed dealkoxylation ofN-alkoxyamides has been developed. This reaction proceeded smoothly with a range ofN-alkoxyamides in the absence of an external reductant, thereby establishing a convenient and reductant-free protocol. In addition, a gram-scale reaction could be achieved. Preliminary mechanistic investigations indicated that β-hydrogen elimination from a palladium alkoxide intermediate generated an intramolecular hydride source.