687639-03-8

Basic information

• Product Name: Acetamide, N-(3-bromo-4-oxocyclohexyl)-
• CAS NO: 687639-03-8
• Molecular Formula: C8H12BrNO2
• Molecular Weight: 234.093
• Mol File: 687639-03-8.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Acetamide, N-(3-bromo-4-oxocyclohexyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Acetamide, N-(3-bromo-4-oxocyclohexyl)-(687639-03-8)
• EPA Substance Registry System: Acetamide, N-(3-bromo-4-oxocyclohexyl)-(687639-03-8)

Safety Data

• Hazardous Substances Data: 687639-03-8(Hazardous Substances Data)

Usage

General Description

Acetamide, N-(3-bromo-4-oxocyclohexyl)- is a chemical compound with the molecular formula C8H11BrNO2. It is a derivative of acetamide, with a bromine atom and a cyclohexyl ring attached to the amide nitrogen. Acetamide, N-(3-bromo-4-oxocyclohexyl)- is used in organic synthesis and pharmaceutical research as a building block for the synthesis of various biologically active molecules. It may also have potential applications in the development of new drugs or medical treatments. However, as with any chemical compound, proper handling and safety precautions should be followed when working with Acetamide, N-(3-bromo-4-oxocyclohexyl)- to ensure the safety of researchers and the surrounding environment.

Upstream product

• 27514-08-5 N-(4-oxocyclohexyl)acetamide 
• 23363-88-4 trans-N-acetyl-4-hydroxycyclohexylamine 

Downstream Products

• 104617-50-7 N-(2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)acetamide hydrobromide 
• 106006-83-1 2,6-diamino-4,5,6,7-tetrahydro-benzthiazole 
• 106092-11-9 (R)-4,5,6,7-tetrahydrobenzo[1,2-d]thiazole-2,6-diamine 
• 106092-09-5 (S)-4,5,6,7-tetrahydrobenzo[d]thiazol-2,6-diamine 
• 1262552-31-7 1-((S)-2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)-3-(2-fluorophenyl)thiourea 
• 1262552-30-6 1-((S)-2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)-3-(3-methoxyphenyl)thiourea 
• 1262552-29-3 1-((S)-2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)-3-(3-chlorophenyl)thiourea 
• 1262552-28-2 1-((S)-2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)-3-(4-fluorophenyl)thiourea 
• 1262552-27-1 1-((S)-2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)-3-(4-methoxyphenyl)thiourea 
• 1262552-35-1 1-((S)-2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)-3-phenylthiourea 
• 1262552-34-0 1-((S)-2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)-3-(4-chlorophenyl)thiourea 
• 1262552-33-9 1-((S)-2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)-3-(2,4-dichlorophenyl)thiourea 
• 1262552-32-8 1-((S)-2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)-3-(2-chlorophenyl)thiourea 
• 372982-92-8 tert-butyl 2-[[(1R)-2-((2S)-{[(2-amino-4,5,6,7-tetrahydro-1,3-benzothiazol-6-yl)amino]carbonyl}pyrrolidinyl)-1-(cyclohexylmethyl)-2-oxoethyl](tert-butyoxycarbonyl)amino]acetate 

Relevant articles and documents

Crystallization process of diamino -4, 5, 6, 7- tetrahydrobenzothiazole

Reaction and formation, of the product, with acetone as a reaction solvent, takes place in acetone as a reaction solvent to give the product, as a raw material, with acetone as a reaction solvent to obtain the mixed rotation product, and then recrystallize the reaction solvent with water: to obtain the reaction . Example, shows that the reaction time, is greatly shortened by taking the product, as a reaction solvent by taking acetone as a reaction solvent as a raw material A; dropwise to obtain the reaction and the reaction of the reaction, solvent with water and dissolving: dropwise with acetone as a reaction solvent in step A as a reaction solvent in an existing production process by, acetone, L - taking acetone as a, reaction solvent to prepare a reaction solvent for, the whole process, to prepare a crystal, by taking acetone as, a reaction solvent to prepare a reaction solvent by taking acetone as a reaction solvent to prepare a. reaction solvent by taking acetone as a reaction solvent.

Preparation method of pramipexole intermediate 2, 6-diamino-4, 5, 6, 7-tetrahydrobenzothiazole

The invention discloses a preparation method of pramipexole intermediate 2, 6-diamino-4, 5, 6, 7-tetrahydrobenzothiazole. According to the method, 4-acetamido cyclohexanol is taken as a starting material, hydrobromic acid is taken as an oxidizing agent an

Synthesis and identification of a new class of (S)-2,6-diamino-4,5,6,7- tetrahydrobenzo[d]thiazole derivatives as potent antileukemic agents

Benzothiazoles are multitarget agents with broad spectrum of biological activity. Among the antitumor agents discovered in recent years, the identification of various 2-(4-aminophenyl) benzothiazoles as potent and selective antitumor drugs against different cancer cell lines has stimulated remarkable interest. Some of the benzothiazoles are known to induce cell cycle arrest, activation of caspases and interaction with DNA molecule. Based on these interesting properties of benzothiazoles and to obtain new biologically active agents, a series of novel 4,5,6,7-tetrahydrobenzo[d]thiazole derivatives 5(a-i) were synthesized and evaluated for their efficacy as antileukemic agents in human leukemia cells (K562 and Reh). The chemical structures of the synthesized compounds were confirmed by 1H NMR, LCMS and IR analysis. The cytotoxicity of these compounds were determined using trypan blue exclusion, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and lactate dehydrogenase (LDH) assays. Results showed that, these compounds mediate a significant cytotoxic response to cancer cell lines tested. We found that the compounds having electron withdrawing groups at different positions of the phenyl ring of the thiourea moiety displayed significant cytotoxic effect with IC50 value less than 60 μM. To rationalize the role of electron withdrawing group in the induction of cytotoxicity, we have chosen molecule 5g (IC 50 ～15 μM) which is having chloro substitution at ortho and para positions. Flow cytometric analysis of annexin V-FITC/propidium iodide (PI) double staining and DNA fragmentation suggest that 5g can induce apoptosis. Springer Science + Business Media, LLC 2009.