68840-81-3

Basic information

• Product Name: 2-BENZYL-AZEPANE
• Synonyms: 2-BENZYL-AZEPANE
• CAS NO: 68840-81-3
• Molecular Formula: C₁₃H₁₉N
• Molecular Weight: 0
• Mol File: 68840-81-3.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-BENZYL-AZEPANE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BENZYL-AZEPANE(68840-81-3)
• EPA Substance Registry System: 2-BENZYL-AZEPANE(68840-81-3)

Safety Data

• Hazardous Substances Data: 68840-81-3(Hazardous Substances Data)

Upstream product

• 19165-94-7 1-benzylcyclohexan-1-amine 
• 946-33-8 2-benzylcyclohexan-1-one 
• 111-49-9 hexamethylene imine 
• 2214-81-5 tetrahydroazepine 
• 6921-34-2 benzylmagnesium chloride 
• 114635-55-1 C₁₉H₂₂N₂O₅S 
• 114635-72-2 N-(1-benzylcyclohexyl)hydroxylamine 
• 70367-75-8 1-benzyl-1-nitrocyclohexane 
• 62596-18-3 7-benzylazepan-2-one 
• 154188-72-4 7-phenylhept-6-yn-1-amine 
• 3338-08-7 2-benzyl-3,4,5,6-tetrahydro-2H-azepin 

Downstream Products

• 68840-87-9 2-(4-nitrobenzyl)perhydroazepine 
• 68840-95-9 2-benzyl-1-methyl-azepane 
• 114635-83-5 1-(p-nitrobenzoyl)-2-benzylazacycloheptane 

Relevant articles and documents

ATM KINASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF

Provided are certain ATM kinase inhibitors of Formula (I). Also provided herein are compositions of such compounds, and methods of their use.

Pd(OAc)2-catalyzed carbonylation of amines

A phosphine-free catalytic system [Pd(OAc)2-Cu(OAc) 2-air] induced a substrate-specific carbonylation of amines in boiling toluene under CO gas (1 atm). Symmetrical N,N′-dialkylureas were obtained by the carbonylation of primary amines. N,N,N′-Trialkylureas were selectively formed by addition of a secondary amine to the above reaction vessel. Secondary amines did not give tetraalkylureas. However, dialkylamines with a phenyl group on their alkyl chains, such as N-monoalkylated benzylic amine or phenethylamine derivatives, underwent a direct aromatic carbonylation to afford five- or six-membered benzolactams. In the carbonylation, the chelation effect or steric repulsion between Pd(II) and the meta-substituent in the ortho-palladation and the ring sizes of cyclopalladation products that were formed prior to carbonylation were found to generate good site selectivity and increase the reaction rate. In contrast, carbonylation of ω- arylalkylamines with a hydroxyl group gave neither ureas nor benzolactams but instead produced 1,3-oxazolidinones smoothly. Hydrochlorides of amines also underwent carbonylation to afford the corresponding amides under the conditions used. This procedure made it possible to prepare ureas of amino acid esters and N-alkylcarbamates in practical yields.

Carbon-to-Nitrogen Rearrangement in N-(Arylsulfonoxy)amines as a Route to Azacyclic Compounds

A series of cyclic amines 1-10 was converted to the N-((p-nitrophenyl)sulfonoxy)amine derivatives with (p-nitrophenyl)sulfonyl peroxide.These compounds rearranged to ring-expanded cyclic imines in fair to good yields.Conversion of the amine to its hydroxy