69388-79-0Relevant articles and documents
An efficient method for the synthesis of sulbactam pivoxil
Changov, Lubomir S.,Vassileva, Blagina K.,Confino, Maya N.,Agapova, Nely N.
, p. 134 - 135 (2000)
Sulbactam pivoxil, a prodrug of the β-lactamase inhibitor sulbactam, was prepared in high yield by reacting the sodium salt of sulbactam with chloromethyl pivalate in a polar solvent, then diluting the reaction mixture with water and isolating the product by filtration. Dimethyl sulfoxide was found to be the solvent of choice among several aprotic organic solvents. Copyright (C) 2000 Elsevier Science S.A.
A novel synthetic method for penicillanic acid derivatives by electroreduction
Ikeda,Tsukamoto,Nishiguchi,Hirashima
, p. 1976 - 1981 (2007/10/02)
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6,6-dihalopenicillanic acid 1,1-dioxides and process
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, (2008/06/13)
A process for the preparation of penicillanic acid 1,1-dioxide and esters thereof readily hydrolyzable in vivo, which comprises oxidation of a 6,6-dihalopenicillanic acid, or an ester thereof readily hydrolyzable in vivo, to the corresponding 6,6-dihalopenicillanic acid 1,1-dioxide or ester thereof, followed by dehalogenation (e.g. by hydrogenolysis). The 6,6-dihalopenicillanic acid 1,1-dioxides and esters thereof readily hydrolyzable in vivo are novel intermediates. Penicillanic acid 1,1-dioxide, and esters thereof readily hydrolyzable in vivo, are known compounds which are useful as beta-lactamase inhibitors and for enhancing the effectiveness of certain beta-lactam antibiotics (e.g. the penicillins) in the treatment of bacterial infections in mammals, particularly humans.