69499-02-1

Basic information

• Product Name: 11-(4-tert-butyl-piperazin-1-yl)-2-chloro-dibenzo[b,f][1,4]thiazepine
• Synonyms: 11-(4-tert-butyl-piperazin-1-yl)-2-chloro-dibenzo[b,f][1,4]thiazepine
• CAS NO: 69499-02-1
• Molecular Weight: 385.961
• Mol File: 69499-02-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 11-(4-tert-butyl-piperazin-1-yl)-2-chloro-dibenzo[b,f][1,4]thiazepine(CAS DataBase Reference)
• NIST Chemistry Reference: 11-(4-tert-butyl-piperazin-1-yl)-2-chloro-dibenzo[b,f][1,4]thiazepine(69499-02-1)
• EPA Substance Registry System: 11-(4-tert-butyl-piperazin-1-yl)-2-chloro-dibenzo[b,f][1,4]thiazepine(69499-02-1)

Safety Data

• Hazardous Substances Data: 69499-02-1(Hazardous Substances Data)

Upstream product

• 3159-04-4 2-chlorodibenzo-1,4-thiazepin-11(10H)-one 
• 38216-72-7 1-(1,1-dimethylethyl)-piperazine 

Relevant articles and documents

Dibenzo-epines: Effect of the basic side-chain on neuroleptic activity

Structure-activity relationships in a series of dibenzo[b,f][1,4]thiazepines and -oxazepines and dibenzo[b,e][1,4]diazepines having different basic substituents in the 11-position were studied with reference to their neuroleptic activity. A high degree of structure-specificity was found for the piperazinyl moiety as well as for the distances between the distal nitrogen atom of this group and the tricyclic ring system, which distances are probably of importance for receptor binding. It was shown that the N-oxides of the neuroleptic agents clotiapine, loxapine and clozapine were inactive in in vitro binding tests involving central dopaminergic receptors, and it is very likely therefore that the in vivo activity of these N-oxides in the rat is due to their enzymatic reduction to the active parent compounds. All derivatives having a basic side-chain other than N-alkylpiperazinyl were inactive neuroleptically, with the exception of the N-methyl-4-piperidyl derivative which showed relatively weak effects.