6952-67-6

Basic information

• Product Name: NSC47034
• Synonyms: NSC47034;2-(m-Nitrophenyl)-1,3-dioxolane;2β-(3-Nitrophenyl)-1,3-dioxolane;3-Nitrobenzaldehyde ethylene acetal
• CAS NO: 6952-67-6
• Molecular Formula: C₉H₉NO₄
• Molecular Weight: 195.1721
• Mol File: 6952-67-6.mol
• Article Data: 34

Chemical Properties

• Boiling Point: 310.4°Cat760mmHg
• Flash Point: 149.4°C
• Appearance: /
• Density: 1.329g/cm³
• Vapor Pressure: 0.0011mmHg at 25°C
• Refractive Index: 1.568
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: NSC47034(CAS DataBase Reference)
• NIST Chemistry Reference: NSC47034(6952-67-6)
• EPA Substance Registry System: NSC47034(6952-67-6)

Safety Data

• Hazardous Substances Data: 6952-67-6(Hazardous Substances Data)

Usage

General Description

NSC47034 is a chemical compound that has been studied for its potential antitumor activity. It has been shown to inhibit the growth of cancer cells and induce apoptosis, or programmed cell death, in various cancer cell lines. NSC47034 has also been found to disrupt the formation of blood vessels that supply tumors, known as angiogenesis, which is essential for tumor growth and metastasis. NSC47034 also exhibits anti-inflammatory properties, reducing the production of inflammatory mediators and cytokines in cancer cells. Overall, NSC47034 shows promise as a potential anticancer agent and a possible treatment for inflammatory-related diseases.

InChI:InChI=1/C9H9NO4/c11-10(12)8-3-1-2-7(6-8)9-13-4-5-14-9/h1-3,6,9H,4-5H2

Upstream product

• 99-61-6 3-nitro-benzaldehyde 
• 100-52-7 benzaldehyde 
• 107-07-3 2-chloro-ethanol 
• 96206-46-1 2-{[(3-nitrophenyl)methyl]oxy}ethanol 
• 107-21-1 ethylene glycol 

Downstream Products

• 89303-50-4 2-(4-phenylsulfonylmethyl-5-nitrophenyl)-1,3-dioxolane 
• 89303-40-2 2-(2-phenylsulfonylmethyl-5-nitrophenyl)-1,3-dioxolane 
• 93244-99-6 2-/2-(1,3-doxolanyl)/-6-nitrobenzyl phenyl sulfone 
• 105003-92-7 4-<2-(1,3-dioxolanyl)>-2-nitrophenylacetonitrile 
• 105003-91-6 2-<2-(1,3-dioxolanyl)>-6-nitrophenylacetonitrile 
• 6398-87-4 3-aminobenzaldehyde ethylene acetal 

Relevant articles and documents

2-(3-nitrophenyl)-1,3-dioxolane at 150 K

The title compound, C9H9NO4, is an intermediate in the synthesis of polyvinylaminobenzaldehyde azo dyes. The dioxolane ring displays an envelope conformation with the tertiary C atom deviating from the plane of the remaini

Application of poly(Vinylbenzyltrimethylammonium tribromide) resin as an efficient polymeric catalyst in the acetalization and diacetylation of benzaldehydes

The applications of a new supported tribromide reagent (poly(vinylbenzyltrimethylammonium tribromide) resin) were reported. This supported tribromide resin was used as a catalyst in the acetalization and diacetylation of benzaldehydes under mild conditions with high efficiency. The effects of solvents, and amount of the supported tribromide resin on the reactions were investigated. Under the optimal conditions, most of acetal and 1,1-diacetates of benzaldehydes were selectively obtained in excellent yields.

4,6-Substituted-1H-Indazoles as potent IDO1/TDO dual inhibitors

Indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan 2,3-dioxygenase (TDO) are constitutively overexpressed in many types of cancer cells and exert important immunosuppressive functions. In this article, a series of 4,6-substituted-1H-indazole derivatives were synthesized and evaluated the inhibitory activities against IDO1 and TDO, as well as their structure-activity relationships (SARs). Among these, compound 35 displayed the most IDO1 inhibitory potency with an IC50 value of 0.74 μM in an enzymatic assay and 1.37 μM in HeLa cells. Quantitative analysis of the Western blot results indicated that 35 significantly decreased the INFγ-induced IDO1 expression in a concentration-dependent manner. In addition, 35 showed promising TDO inhibition with an IC50 value of 2.93 μM in the enzymatic assay and 7.54 μM in A172 cells. Moreover, compound 35 exhibited in vivo antitumor activity in the CT26 xenograft model. These findings suggest that 1H-indazole derivative 35 is a potent IDO1/TDO dual inhibitor, and has the potential to be developed for IDO1/TDO-related cancer treatment.