6952-68-7

Basic information

• Product Name: [1,2,4]TRIAZOLO[4,3-A]PYRIDINE-3-THIOL
• Synonyms: CHEMBRDG-BB 4012392;AKOS BBS-00006571;[1,2,4]TRIAZOLO[4,3-A]PYRIDINE-3-THIOL;[1,2,4]Triazol[4,3-a]pyridine-3-thiol;1,2,4-Triazolo[4,3-a]pyridine-3(2H)-thione;3-Sulphanyl[1,2,4]triazolo[4,3-a]pyridine;{3-Mercaptotriazolo[4,3-a]pyridine};{s-Triazolo[4,3-a]pyridine-3(2H)-thione}
• CAS NO: 6952-68-7
• Molecular Formula: C₆H₅N₃S
• Molecular Weight: 151.19
• Mol File: 6952-68-7.mol
• Article Data: 3

Chemical Properties

• Melting Point: 209-210℃
• Boiling Point: 235.1±23.0℃ (760 Torr)
• Flash Point: 96.0±22.6℃
• Appearance: /
• Density: 1.49±0.1 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 0.0511mmHg at 25°C
• Refractive Index: 1.784
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility: DMSO (Slightly), Methanol (Slightly, Heated)
• Stability: Air Sensitive
• CAS DataBase Reference: [1,2,4]TRIAZOLO[4,3-A]PYRIDINE-3-THIOL(CAS DataBase Reference)
• NIST Chemistry Reference: [1,2,4]TRIAZOLO[4,3-A]PYRIDINE-3-THIOL(6952-68-7)
• EPA Substance Registry System: [1,2,4]TRIAZOLO[4,3-A]PYRIDINE-3-THIOL(6952-68-7)

Safety Data

• Hazard Codes: Xn:Harmful
• Statements: R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
• Safety Statements: S36/37:Wear suitable protective clothing and gloves.
• HazardClass: IRRITANT
• Hazardous Substances Data: 6952-68-7(Hazardous Substances Data)

Usage

General Description

[1,2,4]Triazolo[4,3-a]pyridine-3-thiol is a chemical compound with the molecular formula C6H5N5S. It is a heterocyclic compound with a five-membered ring containing nitrogen and sulfur atoms. [1,2,4]TRIAZOLO[4,3-A]PYRIDINE-3-THIOL is a thiol, which means it contains a sulfur atom attached to a hydrogen atom. It has potential applications in pharmaceuticals and material science due to its unique structure and properties. Additionally, it can be used as a building block in organic synthesis to create new compounds with desirable properties. Its structure and properties make it an interesting and useful compound for various scientific and industrial applications.

InChI:InChI=1/C6H5N3S/c10-6-8-7-5-3-1-2-4-9(5)6/h1-4H,(H,8,10)

Upstream product

• 4930-98-7 pyrid-2-ylhydrazine 
• 103-72-0 phenyl isothiocyanate 
• 120-82-1 1,2,4-Trichlorobenzene 
• 75-15-0 carbon disulfide 
• 109-04-6 2-bromo-pyridine 
• 64-17-5 ethanol 
• 584-10-1 potassium trithiocarbonate 
• 64-19-7 acetic acid 

Downstream Products

• 1205852-96-5 4-([1,2,4]triazolo[4,3-a]pyridin-3-ylsulphanyl)aniline 
• 1205853-08-2 phenyl [6-([1,2,4]triazolo[4,3-a]pyridin-3-ylsulphanyl)-1,3-benzothiazol-2-yl]carbamate 
• 115762-17-9 3-((2-(4-(2,4-difluorophenyl)-piperazin-1-yl)ethyl)thio)-[1,2,4]triazolo[4,3-a]pyridine 
• 1205852-97-6 3-[(4-nitrophenyl)sulphanyl][1,2,4]triazolo[4,3-a]pyridine 
• 124435-44-5 3-{2-[5-(4-Methoxy-phenyl)-[1,3,4]oxadiazol-2-yl]-ethylsulfanyl}-[1,2,4]triazolo[4,3-a]pyridine 
• 124435-45-6 3-{2-[5-(4-Chloro-phenyl)-[1,3,4]oxadiazol-2-yl]-ethylsulfanyl}-[1,2,4]triazolo[4,3-a]pyridine 
• 124453-95-8 3-[2-(5-p-Tolyl-[1,3,4]oxadiazol-2-yl)-ethylsulfanyl]-[1,2,4]triazolo[4,3-a]pyridine 
• 124435-46-7 3-[2-(5-m-Tolyl-[1,3,4]oxadiazol-2-yl)-ethylsulfanyl]-[1,2,4]triazolo[4,3-a]pyridine 
• 124435-43-4 3-<(5-phenyl-1,3,4-oxadiazol-2-yl)ethylthio>-1,2,4-triazolo<4,3-a>pyridine 

Relevant articles and documents

Identification and in-vitro ADME assessment of a series of novel anti-malarial agents suitable for hit-to-lead chemistry

Triage of a set of antimalaria hit compounds, identified through high throughput screening against the Chloroquine sensitive (3D7) and resistant (Dd2) parasite Plasmodium falciparum strains identified several novel chemotypes suitable for hit-to-lead chemistry investigation. The set was further refined through investigation of their in vitro ADME properties, which identified templates with good potential to be developed further as antimalarial agents. One example was profiled in an in vivo murine Plasmodium berghei model of malaria infection.

Antiviral imidazo- and triazolo-pyridines

Thioacetonitrile of imidazo- and triazolo pyridines and their use as antiviral agents are disclosed.