69999-16-2

Basic information

• Product Name: 2,3-Dihydrobenzofuranyl-5-acetic acid
• Synonyms: 2,3-DIHYDROBENZOFURANOYL-5-ACETIC ACID;Darifenacin Intermediate 1;2-(2,3-Dihydrobenzofuran-5-yl)acetic acid;(2,3-dihydrobenzofuran-5-yl)acetic acid (Darifenacin);2,3-Dihydrobenzofuranacetic acid;2,3-Dihydro-5-benzofuranacetic acid;2,3-Dihydrobenzofuranyl-5-acetic acid;2-(2,3-dihydro-1-benzofuran-5-yl)acetic acid
• CAS NO: 69999-16-2
• Molecular Formula: C₁₀H₁₀O₃
• Molecular Weight: 178.19
• EINECS: 1806241-263-5
• Product Categories: Pharmaceutical material and intermeidates;Fluorobenzene;APIs Intermediate;Acetics acid and esters;Aromatics Compounds;Furans;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Aromatics, Heterocycles, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 69999-16-2.mol
• Article Data: 6

Chemical Properties

• Melting Point: 105-107°C
• Boiling Point: 345.8 °C at 760 mmHg
• Flash Point: 142.1 °C
• Appearance: white to light yellow crystal powder
• Density: 1.3 g/cm³
• Vapor Pressure: 2.29E-05mmHg at 25°C
• Refractive Index: 1.594
• Storage Temp.: 2-8°C
• Solubility: Chloroform
• PKA: 4.36±0.10(Predicted)
• CAS DataBase Reference: 2,3-Dihydrobenzofuranyl-5-acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-Dihydrobenzofuranyl-5-acetic acid(69999-16-2)
• EPA Substance Registry System: 2,3-Dihydrobenzofuranyl-5-acetic acid(69999-16-2)

Safety Data

• Hazardous Substances Data: 69999-16-2(Hazardous Substances Data)

Usage

Chemical Properties

white to light yellow crystal powde

InChI:InChI=1/C10H10O3/c11-10(12)6-7-1-2-9-8(5-7)3-4-13-9/h1-2,5H,3-4,6H2,(H,11,12)

Upstream product

• 90843-31-5 1-(2,3-dihydrobenzofuran-5-yl)ethanone 
• 155852-41-8 methyl 2-(2,3-dihydrobenzofuran-5-yl)acetate 
• 142935-60-2 benzofuran-5-yl-acetic acid 
• 121638-36-6 methyl 2-(benzofuran-5-yl)acetate 
• 156-38-7 4-hydroxyphenylacetate 
• 79002-49-6 ethyl 2( 2,3-dihydro-1-benzofuran-5-yl)oxoacetate 
• 496-16-2 2.3-dihydrobenzofuran 
• 4755-77-5 Ethyl oxalyl chloride 
• 97483-11-9 2-(2,3-dihydrobenzofuran-5-yl)acetothiomorpholide 

Downstream Products

• 87776-76-9 5-(2-hydroxyethyl)-2,3-dihydrobenzofuran 
• 188862-35-3 5-(bromomethyl)benzofuran 
• 155852-41-8 methyl 2-(2,3-dihydrobenzofuran-5-yl)acetate 
• 127264-14-6 2,3-dihydro-5-(2-bromoethyl)benzofuran 
• 945915-86-6 methyl [1-cyclohexylmethyl-2-(2,3-dihydro-benzofuran-5-ylmethyl)-1H-benzoimidazol-5-yl]carbamate 

Relevant articles and documents

Novel preparation method of darifenacin intermediate 2,3-dihydro-5-benzofuran acetic acid

The invention relates to a novel preparation method of a darifenacin intermediate 2,3-dihydro-5-benzofuran acetic acid. The method comprises the following steps: by taking 2,3-dihydrobenzofuran as aninitial raw material in the presence of a Lewis acid, carrying out a Friedel-Crafts acylation reaction with ethyl oxalyl monochloride so as to obtain a corresponding acyl compound; hydrolyzing to obtain alpha-ketonic acid sodium salt; reducing carbonyl into methylene by utilizing a Wolff-Kishner-HuangMinlong reaction, and acidizing, thereby obtaining the 2,3-dihydro-5-benzofuran acetic acid. The method disclosed by the invention is simple, convenient and safe, cheap and readily available in reactive raw materials and high in reaction yield and is particularly suitable for industrialized production of the 2,3-dihydro-5-benzofuran acetic acid.

SUBSTITUTED PYRROLIDINES

Disclosed herein are substituted pyrrolidine-based muscarinic receptor modulators of Formula I, process of preparation thereof, pharmaceutical compositions thereof, and methods of use thereof.

(2,3-dihydro-5-benzofuranyl)-acetonitrile

The novel compound (2,3-dihydro-5-benzofuranyl)-acetonitrile is prepared by chloromethylating 2,3-dihydro-benzofuran and reacting the resulting 2,3-dihydro-5-chloromethyl-benzofuran with a cyanide. (2,3-Dihydro-5-benzofuranyl)-acetonitrile can be converted by saponification to (2,3-dihydro-5-benzofuranyl)-acetic acid, an important intermediate for the manufacture of various pharmaceutical active substances. This intermediate has hitherto been obtainable only by a laborious procedure and in low yields.