87776-76-9

Basic information

• Product Name: 2,3-Dihydro-5-benzofuranethanol
• Synonyms: 2-(2,3-Dihydrobenzofuran-5-yl)ethanol;2,3-Dihydro-5-benzofuranethanol;5-(2-Hydroxyethyl)-2,3-dihydrobenzofuran;2,3-dihydrobenzofuran-5-ethanol
• CAS NO: 87776-76-9
• Molecular Formula: C₁₀H₁₂O₂
• Molecular Weight: 164.2
• Mol File: 87776-76-9.mol
• Article Data: 19

Chemical Properties

• Boiling Point: 295 °C
• Flash Point: 135 °C
• Appearance: /
• Density: 1.173
• Vapor Pressure: 0.000717mmHg at 25°C
• Refractive Index: 1.579
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2,3-Dihydro-5-benzofuranethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-Dihydro-5-benzofuranethanol(87776-76-9)
• EPA Substance Registry System: 2,3-Dihydro-5-benzofuranethanol(87776-76-9)

Safety Data

• Hazardous Substances Data: 87776-76-9(Hazardous Substances Data)

Usage

Uses

2,3-Dihydro-5-benzofuranethanol is an intermediate in the synthesis of Darifenacin (D193400, HBr); a medication used to treat urinary incontinence. It works by blocking the M3 muscarinic acetylcholine receptor.

InChI:InChI=1/C10H12O2/c11-5-3-8-1-2-10-9(7-8)4-6-12-10/h1-2,7,11H,3-6H2

Upstream product

• 156-38-7 4-hydroxyphenylacetate 
• 121638-36-6 methyl 2-(benzofuran-5-yl)acetate 
• 142935-60-2 benzofuran-5-yl-acetic acid 
• 79002-49-6 ethyl 2( 2,3-dihydro-1-benzofuran-5-yl)oxoacetate 
• 496-16-2 2.3-dihydrobenzofuran 
• 69999-18-4 ethyl 2,3-dihydrobenzofuran-5-ylacetate 
• 943589-92-2 2-(2,3-dihydrobenzofuran-5-yl)acetaldehyde bisulfitic complex 
• 155852-41-8 methyl 2-(2,3-dihydrobenzofuran-5-yl)acetate 
• 69999-16-2 2,3-dihydrobenzofuran-5-acetic acid 

Downstream Products

• 79679-49-5 2-(2,3-dihidrobenzofuran-5-yl)ethyl tosylate 
• 133099-07-7 (S)-darifenacin hydrobromide 
• 943034-50-2 2-(2,3-dihydrobenzofuran-5-yl)ethylchloride 
• 127264-14-6 2,3-dihydro-5-(2-bromoethyl)benzofuran 
• 1423014-75-8 C₂₃H₂₅NO₃ 

Relevant articles and documents

Highly sulphated cellulose: a versatile, reusable and selective desilylating agent for deprotection of alcoholic TBDMS ethers

A mild, efficient and rapid protocol was developed for the deprotection of alcoholic TBDMS ethers using a recyclable, eco-friendly highly sulphated cellulose sulphate acid catalyst in methanol. This acid catalyst selectively cleaves alcoholic TBDMS ethers in bis-TBDMS ethers containing both alcoholic and phenolic TBDMS ether moieties.

Darifenacin intermediate 2, 3 - dihydro - 5 - benzofuran acetic acid preparation new method of (by machine translation)

The invention relates to a darifenacin intermediate - 2, 3 - dihydro - 5 - benzofuran acetic acid. By the P-hydroxy-acetic acid and bromo acetaldehyde acetal as the starting material, the presence of O - alkylation reaction under a condition of the corresponding ether compound; then by esterification reaction to obtain the corresponding ester; in PPA (poly phosphoric acid) under the action of the, cyclization to obtain 2, 3 - benzofuran - 5 - acetate; 2, 3 - benzofuran - 5 - acetic acid layer which hydrolysis, to acidify the corresponding carboxylic acid; obtained by catalytic hydrogenation of 2, 3 - dihydro - 5 - benzofuran acetic acid; or the first 2, 3 - benzofuran - 5 - acetate obtained by catalytic hydrogenation of 2, 3 - dihydro - 5 - benzofuran acetic acid esters; and hydrolyzed, acidified to obtain 2, 3 - dihydro - 5 - benzofuran acetic acid. The method of the invention by simple and safe, each reaction raw materials are cheap and easy to obtain, the reaction yield is high, and is particularly suitable for industrial production of 2, 3 - dihydro - 5 - benzofuran acetic acid. (by machine translation)

OXAZOLE AND THIAZOLE DERIVATIVES AND THEIR USES

A quaternary ammonium compound of formula (I) having M3 receptor antagonist activity; a composition comprising such a compound; the use of such a compound in therapy (such as asthma or COPD); and a method of treating a patient with such a compound.