701-37-1

Basic information

• Product Name: 2-(3-bromophenyl)-2-oxoacetaldehyde
• Synonyms: 2-(3-bromophenyl)-2-oxoacetaldehyde
• CAS NO: 701-37-1
• Molecular Weight: 213.03
• Mol File: 701-37-1.mol
• Article Data: 17

Chemical Properties

• CAS DataBase Reference: 2-(3-bromophenyl)-2-oxoacetaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-bromophenyl)-2-oxoacetaldehyde(701-37-1)
• EPA Substance Registry System: 2-(3-bromophenyl)-2-oxoacetaldehyde(701-37-1)

Safety Data

• Hazardous Substances Data: 701-37-1(Hazardous Substances Data)

Upstream product

• 18523-22-3 2,3'-dibromoacetophenone 
• 2039-86-3 3-bromostyrene 
• 2142-63-4 1-(3-Bromophenyl)ethanone 

Downstream Products

• 906067-46-7 (3-bromophenyl)-(9H-β-carbolin-1-yl)-methanone 
• 1275575-61-5 1-(3-bromobenzoyl)-9H-β-carboline-3-carboxylic acid 
• 125910-14-7 2-(3-bromophenyl)-2-oxoacetaldehyde oxime 

Relevant articles and documents

C?H Methylation of Iminoamido Heterocycles with Sulfur Ylides**

The direct methylation of N-heterocycles is an important transformation for the advancement of pharmaceuticals, agrochemicals, functional materials, and other chemical entities. Herein, the unprecedented C(sp2)-H methylation of iminoamido heterocycles as nucleoside base analogues is described. Notably, trimethylsulfoxonium salt was employed as a methylating agent under aqueous conditions. A wide substrate scope and excellent level of functional-group tolerance were attained. Moreover, this method can be readily applied to the site-selective methylation of azauracil nucleosides. The feasibility of gram-scale reactions and various transformations of the products highlight the synthetic potential of the developed method. Combined deuterium-labeling experiments aided the elucidation of a plausible reaction mechanism.

SMALL MOLECULE INHIBITORS OF NF-kB INDUCING KINASE

The present invention relates to compounds that inhibit NIK and pharmaceutical compositions comprising such compounds and methods of using the same. These compounds and pharmaceutical compositions are envisaged to be useful for preventing or treating diseases such as cancer (such as B-cell malignancies including leukemias, lymphomas and myeloma), inflammatory disorders, autoimmune disorders, immunodermatologic disorders such as palmoplantar pustulosis and hidradenitis suppurativa, and metabolic disorders such as obesity and diabetes.

Synthesis method of piperazine derivative

The invention discloses a synthesis method of a piperazine derivative, namely 3-(3-nitrophenyl)piperazine-1-tert-butyl carboxylate. 1-(3-nitrophenyl)ethanone is taken as a starting material and is subjected to oxidation, cyclization and Boc protection so