70110-24-6

Basic information

• Product Name: 2-Chloropropionyl chloride
• Synonyms: .alpha.-Chloropropionyl chloride; propanoyl chloride, 2-chloro-; 2-chloropropanoyl chloride; (2S)-2-chloropropanoyl chloride; α-Chloropropionyl chloride; 2-Chloro Propionylchloride; 2-Chloro Propionyl Chloride
• CAS NO: 70110-24-6
• Molecular Formula: C₃H₄Cl₂O
• Molecular Weight: 126.9693
• EINECS: 231-540-7
• Mol File: 70110-24-6.mol
• Article Data: 18

Chemical Properties

• Melting Point: -71℃
• Boiling Point: 110.1°C at 760 mmHg
• Flash Point: 41.8°C
• Density: 1.291g/cm³
• Vapor Pressure: 24.1mmHg at 25°C
• Refractive Index: 1.434
• Water Solubility: MAY DECOMPOSE
• CAS DataBase Reference: 2-Chloropropionyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloropropionyl chloride(70110-24-6)
• EPA Substance Registry System: 2-Chloropropionyl chloride(70110-24-6)

Safety Data

• Hazard Codes: C:Corrosive
• Statements: R10:; R35:
• Safety Statements: S16:; S25:; S36/37/39:; S45:
• Hazardous Substances Data: 70110-24-6(Hazardous Substances Data)

Usage

General Description

2-Chloropropionyl chloride, also known as 2-chloropropanoyl chloride, is a chemical compound with the molecular formula C3H4Cl2O. It is a colorless to pale yellow liquid with a pungent odor, and it is a reactive organic compound in the acyl chloride group. 2-Chloropropionyl chloride is commonly used in the synthesis of pharmaceuticals and agrochemicals, as well as in the production of various chemical intermediates. 2-Chloropropionyl chloride is also a useful reagent in organic chemistry for the introduction of the acyl chloride functional group into organic molecules. However, it is important to handle 2-Chloropropionyl chloride with care, as it is corrosive and can cause severe skin and eye irritation.

Upstream product

• 79-33-4 L-Lactic acid 
• 29617-66-1 (S)-2-chloropropanoic acid 
• 87337-51-7 (+)-2(S)-fluoropropionyl chloride 
• 98-88-4 benzoyl chloride 

Downstream Products

• 40781-50-8 L-α-Chloro-propionsaeure-(m-methoxy-anilid) 
• 40781-38-2 L-α-Chloro-propionsaeure-(p-nitro-anilid) 
• 40781-51-9 L-α-Chloro-propionsaeure-(m-chloro-anilid) 
• 40781-37-1 L-α-Chloropropionsaeure-(p-carbaethoxy-anilid) 
• 40781-56-4 L(-)-α-Chloro-propionsaeure-(o-methyl-anilid) 
• 1436416-07-7 (2S,5R)-2-chloro-N-(2-hydroxy-1-phenylethyl)propanamide 
• 1240349-81-8 2-chloro-N-((R)-2-hydroxy-1-phenylethyl)propionamide 
• 1313441-05-2 (R)-tert-butyl 1-(4-(3-methyl-2-oxo-7-phenyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-6-yl)phenyl)cyclobutylcarbamate 
• 185199-35-3 (S)-(+)-5-(2-chloro-1-oxo)propyl-1,3-dihydro-3,3-dimethyl-2H-indol-2-one 
• 85439-24-3 (+)-2-chloro-1-phenylpropan-1-one 
• 129768-48-5 (S)-2-(α-Chloropropionyl)aminobenzamide 
• 143238-69-1 2'-<6'-((2''S-2''-chloropropanoyl)oxy)>naphthyl 4-decyloxybenzoate 
• 132314-86-4 2-((S)-2-Chloro-propionyloxy)-4-methyl-2-phenyl-pent-4-enoic acid 

Relevant articles and documents

Stereochemical Consequences of Bromine-for-Halogen Substitutions in the Gas Phase

The stereochemistry of translationally excited bromine-for-halogen substitution was studied in gaseous 2(S)- and 2(R)-halopropionyl halides.Net inversion of configuration was observed for 75Br-for-X substitutions with a trend of increasing inversion as the displaced atom was varied in the series, X = F, Cl, Br.A correlation with previous studies on 18F-for-X and 34mCl-for-X substitutions also showed increased inversion with increased mass of the displacing agent.In addition, these recoil atom substitutions showed an apparent independence from the free-energy requirement of reaction.

Discovery of EST73502, a Dual μ-Opioid Receptor Agonist and σ1Receptor Antagonist Clinical Candidate for the Treatment of Pain

The synthesis and pharmacological activity of a new series of 4-alkyl-1-oxa-4,9-diazaspiro[5.5]undecane derivatives as potent dual ligands for the σ1 receptor (σ1R) and the μ-opioid receptor (MOR) are reported. A lead optimization program over the initial 4-aryl analogues provided 4-alkyl derivatives with the desired functionality and good selectivity and ADME profiles. Compound 14u (EST73502) showed MOR agonism and σ1R antagonism and a potent analgesic activity, comparable to the MOR agonist oxycodone in animal models of acute and chronic pain after single and repeated administration. Contrary to oxycodone, 14u produces analgesic activity with reduced opioid-induced relevant adverse events, like intestinal transit inhibition and naloxone-precipitated behavioral signs of opiate withdrawal. These results provide evidence that dual MOR agonism and σ1R antagonism may be a useful strategy for obtaining potent and safer analgesics and were the basis for the selection of 14u as a clinical candidate for the treatment of pain.

THIOTRIAZOLE COMPOUND AND ITS USE IN PARASITIC PROTOZOAL INFECTIONS

The present invention relates to a compound of Formula (I) or tautomers thereof having pharmacological activity, processes for its preparation, pharmaceutical compositions and their use in the treatment of certain parasitic certain parasitic protozoal infections such as malaria, in particular infection by Plasmodium falciparum. (R)-2-((3-(3,5-dichloropyridin-4-yl)-1H-1,2,4-triazol-5-yl)thio)-1-(1H-indol-3-yl)propan-1-one