702-11-4

Basic information

• Product Name: BenzeneMethanaMine, 4-fluoro-N,N-diMethyl-
• Synonyms: BenzeneMethanaMine, 4-fluoro-N,N-diMethyl-
• CAS NO: 702-11-4
• Molecular Formula: C₉H₁₂FN
• Molecular Weight: 153.1966832
• Mol File: 702-11-4.mol
• Article Data: 21

Chemical Properties

• Appearance: /
• CAS DataBase Reference: BenzeneMethanaMine, 4-fluoro-N,N-diMethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: BenzeneMethanaMine, 4-fluoro-N,N-diMethyl-(702-11-4)
• EPA Substance Registry System: BenzeneMethanaMine, 4-fluoro-N,N-diMethyl-(702-11-4)

Safety Data

• Hazardous Substances Data: 702-11-4(Hazardous Substances Data)

Usage

General Description

BenzeneMethanaMine, 4-fluoro-N,N-diMethyl- is a chemical compound with the molecular formula C9H11FN. It is commonly known as 4-fluoro-N,N-diMethylbenzylamine or 4-FDMA and is a derivative of amphetamine. BenzeneMethanaMine, 4-fluoro-N,N-diMethyl- is often used in research settings as a reference standard for forensic and toxicology laboratories. It is known for its psychoactive and stimulant effects and has been identified as a potential designer drug, although its legal status may vary depending on the jurisdiction. 4-FDMA is often sold as a white powder or in tablet form and can be ingested, snorted, or injected. Its effects on the human body include increased energy, alertness, and euphoria, but it can also have negative side effects and be addictive.

Upstream product

• 506-59-2 N,N-dimethylammonium chloride 
• 459-57-4 4-fluorobenzaldehyde 
• 459-56-3 4-fluorobenzylic alcohol 
• 124-40-3 dimethyl amine 
• 50-00-0 formaldehyd 
• 140-75-0 para-fluorobenzylamine 
• 67-56-1 methanol 
• 159979-96-1 4-fluorobenzyl azide 
• 459-46-1 4-Fluorobenzyl bromide 
• 405-66-3 (4-Fluoro-benzyl)-methyl-amine 
• 1194-02-1 4-fluorobenzonitrile 
• 24167-56-4 N,N-dimethyl-4-fluorobenzamide 
• 6274-57-3 (4-bromobenzyl)dimethylamine 
• 922142-70-9 (4-fluorobenzyl)dimethylamine N-oxide 

Downstream Products

• 1192229-93-8 4-fluorobenzyldimethylamine borane 
• 57239-58-4 bis(4-fluorobenzyl) diselenide 
• 1670-17-3 N,N-dimethyl-2,4-dinitroaniline 
• 67751-25-1 1-dimethylamino-1,2-di(methoxycarbonyl)ethene 
• 78974-45-5 1-fluoro-4-((phenylsulfonyl)methyl)benzene 
• 458-76-4 4,4'-difluorobibenzyl 
• 405-50-5 p-Fluorophenylacetic acid 
• 293731-49-4 benzyl 2-(4-fluorophenyl)ethanoate 
• 352-32-9 p-fluorotoluene 
• 243145-83-7 2-[(4-fluorophenyl)methyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 1258839-95-0 ethyl 2-((dimethylamino)methyl)-5-fluorobenzoate 
• 115911-28-9 3-(4-fluorobenzyl)pyridine-2,6-diamine 

Relevant articles and documents

Pd(II)-Mediated C?H Activation for Cysteine Bioconjugation

Selective bioconjugation remains a significant challenge for the synthetic chemist due to the stringent reaction conditions required by biomolecules coupled with their high degree of functionality. The current trailblazer of transition-metal mediated bioconjugation chemistry involves the use of Pd(II) complexes prepared via an oxidative addition process. Herein, the preparation of Pd(II) complexes for cysteine bioconjugation via a facile C?H activation process is reported. These complexes show bioconjugation efficiency competitive with what is seen in the current literature, with a user-friendly synthesis, common Pd(II) sources, and a more cost-effective ligand. Furthermore, these complexes need not be isolated, and still achieve high conversion efficiency and selectivity of a model peptide. These complexes also demonstrate the ability to selectively arylate a single surface cysteine residue on a model protein substrate, further demonstrating their utility.

Palladium-Catalyzed Reductive Aminocarbonylation of Benzylammonium Triflates with o-Nitrobenzaldehydes for the Synthesis of 3-Arylquinolin-2(1 H)-ones

A palladium-catalyzed straightforward procedure for the synthesis of 3-arylquinolin-2(1H)-ones has been developed. The synthesis proceeds through a palladium-catalyzed reductive aminocarbonylation reaction of benzylic ammonium triflates with o-nitrobenzaldehydes, and a wide range of 3-arylquinolin-2(1H)-ones was obtained in moderate to good yields with very good functional group compatibility.

Cu2O-catalyzed C–S coupling of quaternary ammonium salts and sodium alkane-/arene-sulfinates

A new protocol for the synthesis of (enantioenriched) benzylic sulfones via the Cu2O-catalyzed C–S bond cross coupling of alkane-/arene-sulfinates and (enantioenriched) benzylic quaternary ammonium salts has been developed. The product benzylic sulfones were obtained in good to high yields (75–96%). Chiral arylmethyl sulfones with high enantiomeric excess (90–94% ee) were also synthesized in the presence of Cu2O and 1,1′-bis-(diphenylphosphino)ferrocene (dppf).