70644-47-2

Basic information

• Product Name: 2-BENZYLAMINO-6-METHYLPYRIDINE, 99
• Synonyms: 6-methyl-n-(phenylmethyl)-2-pyridinamin;2-BENZYLAMINO-6-METHYLPYRIDINE, 99;N-(benzyl)-6-methylpyridin-2-amine;6-Methyl-N-(phenylmethyl)-2-pyridinamine;2-Pyridinamine, 6-methyl-N-(phenylmethyl)-;6-methyl-N-(phenylmethyl)pyridin-2-amine;benzyl-(6-methyl-2-pyridyl)amine
• CAS NO: 70644-47-2
• Molecular Formula: C₁₃H₁₄N₂
• Molecular Weight: 198.26366
• EINECS: 274-716-9
• Mol File: 70644-47-2.mol
• Article Data: 8

Chemical Properties

• Melting Point: 64-66 °C(lit.)
• Boiling Point: 327.5°C at 760 mmHg
• Flash Point: 151.9°C
• Appearance: /
• Density: 1.107g/cm³
• Vapor Pressure: 0.000201mmHg at 25°C
• Refractive Index: 1.624
• CAS DataBase Reference: 2-BENZYLAMINO-6-METHYLPYRIDINE, 99(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BENZYLAMINO-6-METHYLPYRIDINE, 99(70644-47-2)
• EPA Substance Registry System: 2-BENZYLAMINO-6-METHYLPYRIDINE, 99(70644-47-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 70644-47-2(Hazardous Substances Data)

Usage

General Description

2-Benzylamino-6-methylpyridine is a specialized chemical compound with a high purity rate of 99 percent. It has a complex molecular structure, symbolized by the presence of a pyridine ring a multi-functional group with benzyl amino and methyl groups attached to it. The presence of the functional groups influences its chemical properties and reactivity. Common applications of this chemical compound are often found in research and technical industries, usually as a reagent in various chemical reactions. Due to its specific structure and high purity, it may be used in advanced and specialized fields, such as pharmaceutical research and product development. Also, rigorous safety precautions should be taken when handling 2-Benzylamino-6-methylpyridine due to its potentially hazardous nature.

InChI:InChI=1/C13H14N2/c1-11-6-5-9-13(15-11)14-10-12-7-3-2-4-8-12/h2-9H,10H2,1H3,(H,14,15)

Upstream product

• 1824-81-3 2-Amino-6-methylpyridine 
• 64-18-6 formic acid 
• 100-52-7 benzaldehyde 
• 100-51-6 benzyl alcohol 
• 62135-66-4 N-(6-methylpyridin-2-yl)benzamide 
• 18368-63-3 6-chloro-2-picoline 
• 100-46-9 benzylamine 
• 5315-25-3 2-bromo-6-methylpyridine 
• 109-06-8 α-picoline 
• 98-88-4 benzoyl chloride 

Downstream Products

• 1409949-92-3 C₁₃H₁₃Cl₂CrN₂ 
• 309728-75-4 1-benzyl-7-methyl-2,3-dihydro-1H-[1,8]naphthyridin-4-one O-oxiranylmethyl-oxime 
• 309728-67-4 1-benzyl-7-methyl-2,3-dihydro-1H-[1,8]naphthyridin-4-one oxime 
• 59937-17-6 1-Benzyl-7-methyl-2,3-dihydro-1H-[1,8]naphthyridin-4-one 
• 309728-55-0 3-[benzyl-(6-methyl-pyridin-2-yl)-amino]-propionic acid ethyl ester 

Relevant articles and documents

Nickel?Copper bimetallic mesoporous nanoparticles: As an efficient heterogeneous catalyst for N-alkylation of amines with alcohols

A bimetallic catalyst (Ni/Cu-MCM-41) is prepared via co-condensation method. The latter is characterized by Fourier transform infrared (FT-IR), X-ray powder diffraction (XRD), scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDX), diffuse reflectance spectroscopy (DRS), and nitrogen adsorption–desorption analysis. Catalytic performance of Ni/Cu-MCM-41 is probed in N-alkylation of amines with alcohols through a hydrogen autotransfer process. Noteworthy, this catalytic system appears very efficient for synthesis of a range of secondary and tertiary amines in good to excellent isolated yields. Moreover, the catalyst is successfully recovered and reused four times without notable decrease in its activity.

Hemilabile N-heterocyclic carbene (NHC)-nitrogen-phosphine mediated Ru (II)-catalyzed N-alkylation of aromatic amine with alcohol efficiently

Based on the hemilability, a novel N-heterocyclic carbene (NHC)-nitrogen-phosphine ligand (1) was synthesized, and the combination of it with [Ru(COD)Cl2]n showed the high activity and selectivity with a low Ru loading of 0.1% for the N-alkylation of amine with alcohol. Especially, for these substrates with pyridine backbone, even if the catalyst loading was as low as 0.01%, good yields (81–95%) of the desired products were achieved.

CuI/Oxalic Diamide Catalyzed Coupling Reaction of (Hetero)Aryl Chlorides and Amines

A class of oxalic diamides are found to be effective ligands for promoting CuI-catalyzed aryl amination with less reactive (hetero)aryl chlorides. The reaction proceeds at 120 °C with K3PO4 as the base in DMSO to afford a wide range of (hetero)aryl amines in good to excellent yields. The bis(N-aryl) substituted oxalamides are superior ligands to N-aryl-N′-alkyl substituted or bis(N-alkyl) substituted oxalamides. Both the electronic nature and the steric property of the aromatic rings in ligands are important for their efficiency.